J
Juan Pedro Kusanovic
Researcher at National Institutes of Health
Publications - 251
Citations - 19185
Juan Pedro Kusanovic is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pregnancy & Amniotic fluid. The author has an hindex of 65, co-authored 246 publications receiving 17350 citations. Previous affiliations of Juan Pedro Kusanovic include Detroit Medical Center & Wayne State University.
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Journal ArticleDOI
Chorioamnionitis and increased galectin-1 expression in PPROM –an anti-inflammatory response in the fetal membranes?
Nandor Gabor Than,Sung Su Kim,Asad Abbas,Yu Mi Han,John W. Hotra,Adi L. Tarca,Offer Erez,Derek E. Wildman,Derek E. Wildman,Juan Pedro Kusanovic,Beth L. Pineles,Daniel Montenegro,Samuel S. Edwin,Shali Mazaki-Tovi,Francesca Gotsch,Jimmy Espinoza,Sonia S. Hassan,Sonia S. Hassan,Zoltán Papp,Roberto Romero,Roberto Romero +20 more
TL;DR: Galectin-1 mRNA and protein were detected in amniotic epithelium, chorioamniotic mesodermal cells, and decidual stromal cells.
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Activation of the alternative pathway of complement is a feature of pre-term parturition but not of spontaneous labor at term.
Edi Vaisbuch,Roberto Romero,Roberto Romero,Offer Erez,Offer Erez,Shali Mazaki-Tovi,Shali Mazaki-Tovi,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Eleazar Soto,Zhong Dong,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Sun Kwon Kim,Giovanna Ogge,Percy Pacora,Lami Yeo,Lami Yeo,Sonia S. Hassan,Sonia S. Hassan +19 more
TL;DR: Vaisbuch et al. as discussed by the authors found that high concentrations of fragment Bb (FBb) in maternal blood, as early as the first trimester, are associated with subsequent spontaneous preterm delivery <34 weeks of gestation.
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A molecular signature of an arrest of descent in human parturition.
Pooja Mittal,Pooja Mittal,Roberto Romero,Roberto Romero,Adi L. Tarca,Adi L. Tarca,Sorin Draghici,Sorin Draghici,Chia Ling Nhan-Chang,Chia Ling Nhan-Chang,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,John W. Hotra,Ricardo Gomez,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Deug Chan Lee,Chong Jai Kim,Chong Jai Kim,Sonia S. Hassan,Sonia S. Hassan +20 more
TL;DR: A stereotypic pattern of gene expression in the myometrium of women with an arrest of descent is identified using a genome-wide approach and indicated enrichment of biological processes and molecular functions related to inflammation and muscle function.
Journal ArticleDOI
Personalized assessment of cervical length improves prediction of spontaneous preterm birth: a standard and a percentile calculator.
Dereje W. Gudicha,Roberto Romero,Doron Kabiri,Edgar Hernandez-Andrade,Percy Pacora,Offer Erez,Juan Pedro Kusanovic,Eun Jung Jung,Carmen Paredes,Stanley M. Berry,Lami Yeo,Sonia S. Hassan,Chaur-Dong Hsu,Adi L. Tarca,Adi L. Tarca,Adi L. Tarca +15 more
TL;DR: A customized cervical length standard that considers relevant maternal characteristics and gestational age at sonographic examination and improves the distinction between patients at risk for impending preterm delivery in those who have an episode of preterm labor is created.
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Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generation
Offer Erez,Roberto Romer,Edi Vaisbuch,Tinnakorn Chaiworapongsa,Juan Pedro Kusanovic,Shali Mazaki-Tovi,Francesca Gotsch,Ricardo Gomez,Eli Maymon,Percy Pacora,Samuel Edwin,Chong Jai Kim,Nandor Gabor Than,Pooja Mittal,Lami Yeo,Zhong Dong,Bo Hyun Yoon,Sonia S. Hassan,Moshe Mazor +18 more
TL;DR: There is a distinct difference in the pattern of intra-amniotic thrombin generation between term and preterm parturition, and PTL leading to preterm delivery is associated with an increased intra-ammiotic thROMbin generation regardless of the presence of IAI.