J
Juan Song
Researcher at Katholieke Universiteit Leuven
Publications - 19
Citations - 306
Juan Song is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 8, co-authored 14 publications receiving 221 citations. Previous affiliations of Juan Song include Tianjin Medical University.
Papers
More filters
Journal ArticleDOI
Tudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation.
Chao Su,Chunyan Zhang,Adiam Tecle,Xue Fu,Jinyan He,Juan Song,Wei Zhang,Xiaoming Sun,Yuanyuan Ren,Olli Silvennoinen,Zhi Yao,Xi Yang,Minxin Wei,Jie Yang +13 more
TL;DR: Tudor-SN is identified as a novel co-activator of E2F-1, which could facilitate E2f-1-mediated gene transcriptional activation of target genes, which play essential roles in G1/S transition.
Journal ArticleDOI
X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs.
Vincent Pasque,Vincent Pasque,Rahul Karnik,Constantinos Chronis,Paula Petrella,Justin Langerman,Giancarlo Bonora,Juan Song,Lotte Vanheer,Anupama Sadhu Dimashkie,Alexander Meissner,Kathrin Plath +11 more
TL;DR: It is revealed that X chromosome dosage dictates global DNA methylation levels in iPSCs, and the loss of one of the two X chromosomes in propagating female iPSCS is associated with genome-wide methylation gain.
Journal ArticleDOI
Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells.
Juan Song,David Cano-Rodriquez,Melanie Winkle,Rutger A. F. Gjaltema,Désirée Goubert,Tomasz P. Jurkowski,Irene H. Heijink,Marianne G. Rots,Machteld N. Hylkema +8 more
TL;DR: Efficient SPDEF silencing and downregulation of mucus-related gene expression by epigenetic editing, in human lung epithelial cells is indicated, which opens avenues for epigenetic edited as a novel therapeutic strategy to induce long-lasting mucus inhibition.
Journal ArticleDOI
Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.
Adrian Janiszewski,Irene Talon,Joel Chappell,Samuel Collombet,Juan Song,Natalie De Geest,San Kit To,Greet Bervoets,Oskar Marín-Béjar,Caterina Provenzano,Lotte Vanheer,Jean-Christophe Marine,Florian Rambow,Vincent Pasque +13 more
TL;DR: The timing of transcriptional activation of monoallelically repressed genes during iPSC reprogramming is revealed, and it is suggested that allelic activation involves the combined action of chromatin topology, pluripotency TFs, and chromatin regulators.
Journal ArticleDOI
Poly(A)(+) mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics.
Xingjie Gao,Xue Fu,Juan Song,Yi Zhang,Xiaoteng Cui,Chao Su,Lin Ge,Jie Shao,Jie Shao,Lingbiao Xin,Juha Saarikettu,Mei Mei,Xi Yang,Minxin Wei,Olli Silvennoinen,Zhi Yao,Jinyan He,Jie Yang +17 more
TL;DR: It is demonstrated that Tudor‐SN binds and colocalizes with many core components of SGs, and can regulate the aggregation dynamics of poly(A)+ mRNA‐containing SGs and selectively stabilize the SG‐associated mRNA during cellular stress.