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Samuel Collombet
Researcher at École Normale Supérieure
Publications - 22
Citations - 1586
Samuel Collombet is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Chromatin & Reprogramming. The author has an hindex of 12, co-authored 21 publications receiving 1057 citations. Previous affiliations of Samuel Collombet include European Bioinformatics Institute & National University of Singapore.
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Journal ArticleDOI
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
Ralph Stadhouders,Ralph Stadhouders,Enrique Vidal,François Serra,Bruno Di Stefano,Bruno Di Stefano,François Le Dily,Javier Quilez,Antonio Gomez,Samuel Collombet,Clara Berenguer,Yasmina Cuartero,Jochen Hecht,Guillaume J. Filion,Miguel Beato,Marc A. Marti-Renom,Thomas Graf +16 more
TL;DR: It is concluded that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.
Journal ArticleDOI
C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
Bruno Di Stefano,Jose Luis Sardina,Chris van Oevelen,Samuel Collombet,Eric M Kallin,Guillermo P. Vicent,Jun Lu,Denis Thieffry,Miguel Beato,Thomas Graf +9 more
TL;DR: The authors showed that a pulse of CCAAT/enhancer binding protein-α (C/EBPα) followed by overexpression of the Yamanaka 'OSKM' reprogramming factors leads to fast and very efficient B-cell precursors to induced pluripotent stem (iPS) cells.
Journal ArticleDOI
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Jose Luis Sardina,Samuel Collombet,Tian V. Tian,Antonio Gomez,Bruno Di Stefano,Clara Berenguer,Justin Brumbaugh,Ralph Stadhouders,Carolina Segura-Morales,Marta Gut,Ivo Gut,Simon Heath,Sergi Aranda,Luciano Di Croce,Konrad Hochedlinger,Denis Thieffry,Thomas Graf +16 more
TL;DR: In this article, DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) were observed.
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RSAT 2018: regulatory sequence analysis tools 20th anniversary.
Nga Nguyen,Bruno Contreras-Moreira,Jaime A. Castro-Mondragon,Jaime A. Castro-Mondragon,Walter Santana-Garcia,Raul Ossio,Carla Daniela Robles-Espinoza,Carla Daniela Robles-Espinoza,Mathieu Bahin,Samuel Collombet,Pierre Vincens,Denis Thieffry,Jacques van Helden,Alejandra Medina-Rivera,Morgane Thomas-Chollier +14 more
TL;DR: This Anniversary update gives a 20-year perspective on the RSAT (Regulatory Sequence Analysis Tools) software suite, including updated programs to analyse regulatory variants and tools to extract sequences from a list of coordinates.
Journal ArticleDOI
SPEN integrates transcriptional and epigenetic control of X-inactivation.
François Dossin,Inês Pinheiro,Jan J. Żylicz,Jan J. Żylicz,Julia Roensch,Samuel Collombet,Agnes Le Saux,Tomasz Chelmicki,Mikael Attia,Varun Kapoor,Ye Zhan,Florent Dingli,Damarys Loew,Thomas Mercher,Job Dekker,Job Dekker,Edith Heard +16 more
TL;DR: It is proposed that SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA with the transcription machinery—as well as with nucleosome remodellers and histone deacetylases—at active enhancers and promoters.