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Irene Talon
Researcher at Katholieke Universiteit Leuven
Publications - 15
Citations - 277
Irene Talon is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 6, co-authored 13 publications receiving 130 citations. Previous affiliations of Irene Talon include University of Valencia.
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Journal ArticleDOI
Evaluating totipotency using criteria of increasing stringency.
Eszter Posfai,John P. Schell,John P. Schell,Adrian Janiszewski,Isidora Rovic,Alexander Murray,Brian Bradshaw,Tatsuya Yamakawa,Tine Pardon,Mouna El Bakkali,Irene Talon,Natalie De Geest,Pankaj Kumar,Pankaj Kumar,San Kit To,Sophie Petropoulos,Sophie Petropoulos,Sophie Petropoulos,Andrea Jurisicova,Andrea Jurisicova,Vincent Pasque,Fredrik Lanner,Fredrik Lanner,Janet Rossant +23 more
TL;DR: In this article, the authors define totipotency as the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in vitro remains incompletely understood.
Journal ArticleDOI
Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.
Adrian Janiszewski,Irene Talon,Joel Chappell,Samuel Collombet,Juan Song,Natalie De Geest,San Kit To,Greet Bervoets,Oskar Marín-Béjar,Caterina Provenzano,Lotte Vanheer,Jean-Christophe Marine,Florian Rambow,Vincent Pasque +13 more
TL;DR: The timing of transcriptional activation of monoallelically repressed genes during iPSC reprogramming is revealed, and it is suggested that allelic activation involves the combined action of chromatin topology, pluripotency TFs, and chromatin regulators.
Journal ArticleDOI
X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels.
Juan Song,Adrian Janiszewski,Natalie De Geest,Lotte Vanheer,Irene Talon,Mouna El Bakkali,Taeho Oh,Vincent Pasque +7 more
TL;DR: It is shown that X-dosage regulates the transcriptome, open chromatin landscape, growth, and pluripotency exit largely independently of global DNA methylation.
Journal ArticleDOI
Recent Advances in Understanding the Reversal of Gene Silencing During X Chromosome Reactivation
TL;DR: How new sequencing technologies and reprogramming approaches have enabled recent advances that revealed the timing of transcriptional activation during X chromosome reactivation (XCR) is discussed.
Posted ContentDOI
Defining totipotency using criteria of increasing stringency
Eszter Posfai,John P. Schell,John P. Schell,Adrian Janiszewski,Isidora Rovic,Murray A,Brian Bradshaw,Pardon T,El Bakkali M,Irene Talon,de Geest N,Pankaj Kumar,Pankaj Kumar,San Kit To,Sophie Petropoulos,Sophie Petropoulos,Sophie Petropoulos,Jurisicova A,Pasque,Fredrik Lanner,Fredrik Lanner,Janet Rossant +21 more
TL;DR: It is illustrated how distinct criteria of increasing stringency can be used to judge totipotency by evaluating candidate totipotent cell types in the mouse, including early blastomeres and expanded or extended pluripotent stem cells.