Carlo Battiston

TL;DR: It is shown, using a mouse model of liver cancer, that miR-221 overexpression stimulates growth of tumorigenic murine hepatic progenitor cells, and DNA damage-inducible transcript 4 (DDIT4), a modulator of mTOR pathway, is identified as a bona fide target of miR -221.

TL;DR: MTOR signaling has a critical role in the pathogenesis of HCC, with evidence for the role of RICTOR in hepato-oncogenesis, and a rationale for targeting the mTOR pathway in clinical trials in HCC is established.

TL;DR: RFA is a safe and effective treatment of small HCC in cirrhotics awaiting OLT, although tumor size and time from treatment predict a high risk of tumor persistence in the targeted nodule.

TL;DR: A composite prognostic model for HCC recurrence is developed, based on gene expression patterns in tumor and adjacent tissues, which predict early and overall recurrence in patients with HCC, and complement findings from clinical and pathology analyses.

TL;DR: Molecular data based on gene transcriptional profiles of a 3-gene set allow a reliable diagnosis of early HCC, and GPC3 immunostaining confirms the diagnosis of HCC.