T
Tingsheng Peng
Researcher at University of Texas MD Anderson Cancer Center
Publications - 8
Citations - 541
Tingsheng Peng is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Liposarcoma & Myxoid liposarcoma. The author has an hindex of 8, co-authored 8 publications receiving 467 citations.
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Journal ArticleDOI
MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1α and Enhances β-Catenin Signaling
Pingyu Zhang,Kate Lynn J. Bill,Kate Lynn J. Bill,Kate Lynn J. Bill,Juehui Liu,Eric D. Young,Tingsheng Peng,Svetlana Bolshakov,Aviad Hoffman,Yechun Song,Elizabeth G. Demicco,Dolores Lopez Terrada,Chad J. Creighton,Matthew L. Anderson,Alexander J. Lazar,George G. Calin,Raphael E. Pollock,Dina Lev,Dina Lev,Dina Lev +19 more
TL;DR: The results point to important functions for miR-155 and β-catenin signaling in progression of liposarcoma, revealing mechanistic vulnerabilities that might be exploited for both prognostic and therapeutic purposes.
Journal ArticleDOI
Pleomorphic liposarcoma: clinical observations and molecular variables.
Markus P. Ghadimi,Ping Liu,Tingsheng Peng,Svetlana Bolshakov,Eric D. Young,Keila E. Torres,Chiara Colombo,Aviad Hoffman,Dominique Broccoli,Jason L. Hornick,Alexander J. Lazar,Peter W.T. Pisters,Raphael E. Pollock,Dina Lev,Dina Lev +14 more
TL;DR: Pleomorphic liposarcoma is a rare high‐grade sarcoma that has lipoblastic differentiation and its natural history, patient outcomes, and commonly deregulated protein biomarkers are evaluated.
Journal ArticleDOI
Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations.
Aviad Hoffman,Markus P. Ghadimi,Markus P. Ghadimi,Elizabeth G. Demicco,Chad J. Creighton,Keila E. Torres,Chiara Colombo,Tingsheng Peng,Kristelle Lusby,Davis R. Ingram,Jason L. Hornick,Wei Lie Wang,Vinod Ravi,Alexander J. Lazar,Dina Lev,Raphael E. Pollock +15 more
TL;DR: The authors of this report evaluated the natural history and outcome of patients with MLPS and commonly deregulated protein biomarkers to determine solid prognostic factors and therapeutic targets.
Journal ArticleDOI
Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma
Elizabeth G. Demicco,Keila E. Torres,Markus P. Ghadimi,Chiara Colombo,Svetlana Bolshakov,Aviad Hoffman,Tingsheng Peng,Judith V.M.G. Bovée,Wei Lien Wang,Dina Lev,Alexander J. Lazar +10 more
TL;DR: The findings suggest that activation of the PI3K/Akt pathway via activating mutation of PIK3CA, loss of PTEN, or IGF1R expression have a role in round cell transformation and may provide a therapeutic target inround cell liposarcoma.
Journal ArticleDOI
An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors
Tingsheng Peng,Pingyu Zhang,Jeffery Liu,Theresa Nguyen,Svetlana Bolshakov,Roman Belousov,Eric D. Young,Xiaoke Wang,Kari J. Brewer,Delores H López-Terrada,Andre M. Oliveira,Alexander J. Lazar,Dina Lev +12 more
TL;DR: These newly established cellular and xenograft models can facilitate investigation of liposarcomagenesis, dedifferentiation, and tumor progression and may lead to improved therapeutic strategies for patients afflicted by these unfavorable malignancies.