E
Eric D. Young
Researcher at University of Kansas
Publications - 31
Citations - 1073
Eric D. Young is an academic researcher from University of Kansas. The author has contributed to research in topics: Metastasis & Nerve sheath neoplasm. The author has an hindex of 18, co-authored 31 publications receiving 942 citations. Previous affiliations of Eric D. Young include University of Texas Health Science Center at Houston & Kagoshima University.
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Journal ArticleDOI
MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1α and Enhances β-Catenin Signaling
Pingyu Zhang,Kate Lynn J. Bill,Kate Lynn J. Bill,Kate Lynn J. Bill,Juehui Liu,Eric D. Young,Tingsheng Peng,Svetlana Bolshakov,Aviad Hoffman,Yechun Song,Elizabeth G. Demicco,Dolores Lopez Terrada,Chad J. Creighton,Matthew L. Anderson,Alexander J. Lazar,George G. Calin,Raphael E. Pollock,Dina Lev,Dina Lev,Dina Lev +19 more
TL;DR: The results point to important functions for miR-155 and β-catenin signaling in progression of liposarcoma, revealing mechanistic vulnerabilities that might be exploited for both prognostic and therapeutic purposes.
Journal ArticleDOI
Activated MET Is a Molecular Prognosticator and Potential Therapeutic Target for Malignant Peripheral Nerve Sheath Tumors
Keila E. Torres,Quansheng Zhu,Kate Lynn J. Bill,Kate Lynn J. Bill,Gonzalo Lopez,Gonzalo Lopez,Markus P. Ghadimi,Xianbiao Xie,Eric D. Young,Juehui Liu,Theresa Nguyen,Svetlana Bolshakov,Roman Belousov,Suizhau Wang,Guy Lahat,Jun Liu,Belinda F Hernandez,Alexander J. Lazar,Dina Lev,Dina Lev +19 more
TL;DR: An important role is shown for MET in MPNST, supporting continued investigation of novel anti-MET therapies in this clinical context and Informative prognosticators and novel therapies are crucially needed to improve MPN ST management and outcomes.
Journal ArticleDOI
Pleomorphic liposarcoma: clinical observations and molecular variables.
Markus P. Ghadimi,Ping Liu,Tingsheng Peng,Svetlana Bolshakov,Eric D. Young,Keila E. Torres,Chiara Colombo,Aviad Hoffman,Dominique Broccoli,Jason L. Hornick,Alexander J. Lazar,Peter W.T. Pisters,Raphael E. Pollock,Dina Lev,Dina Lev +14 more
TL;DR: Pleomorphic liposarcoma is a rare high‐grade sarcoma that has lipoblastic differentiation and its natural history, patient outcomes, and commonly deregulated protein biomarkers are evaluated.
Journal ArticleDOI
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Gonzalo Lopez,Keila E. Torres,Juehui Liu,Belinda F Hernandez,Eric D. Young,Roman Belousov,Svetlana Bolshakov,Alexander J. Lazar,John M. Slopis,Ian E. McCutcheon,David J. McConkey,Dina Lev,Dina Lev +12 more
TL;DR: Findings that strongly rationalize clinical evaluation of HDACi in malignant peripheral nerve sheath tumors (MPNST), a class of highly aggressive, therapeutically resistant, and commonly fatal malignancies that occur sporadically or in patients with the inherited neurofibromatosis type-1 (NF1) syndrome, are reported.
Journal ArticleDOI
An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors
Tingsheng Peng,Pingyu Zhang,Jeffery Liu,Theresa Nguyen,Svetlana Bolshakov,Roman Belousov,Eric D. Young,Xiaoke Wang,Kari J. Brewer,Delores H López-Terrada,Andre M. Oliveira,Alexander J. Lazar,Dina Lev +12 more
TL;DR: These newly established cellular and xenograft models can facilitate investigation of liposarcomagenesis, dedifferentiation, and tumor progression and may lead to improved therapeutic strategies for patients afflicted by these unfavorable malignancies.