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Roberto Marasca
Researcher at University of Modena and Reggio Emilia
Publications - 276
Citations - 11875
Roberto Marasca is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Chronic lymphocytic leukemia & Medicine. The author has an hindex of 55, co-authored 249 publications receiving 10522 citations. Previous affiliations of Roberto Marasca include University of Liverpool & University of Pavia.
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Journal ArticleDOI
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Giulia Fabbri,Silvia Rasi,Davide Rossi,Vladimir Trifonov,Hossein Khiabanian,Jing Ma,Adina Grunn,Marco Fangazio,Daniela Capello,Sara Monti,Stefania Cresta,Ernesto Gargiulo,Francesco Forconi,Anna Guarini,Luca Arcaini,Marco Paulli,Luca Laurenti,Luigi Maria Larocca,Roberto Marasca,Valter Gattei,David Oscier,Francesco Bertoni,Charles G. Mullighan,Robin Foà,Laura Pasqualucci,Raul Rabadan,Riccardo Dalla-Favera,Gianluca Gaidano +27 more
TL;DR: Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
Journal ArticleDOI
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
Davide Rossi,Silvia Rasi,Valeria Spina,Alessio Bruscaggin,Sara Monti,Carmela Ciardullo,Clara Deambrogi,Hossein Khiabanian,Roberto Serra,Francesco Bertoni,Francesco Forconi,Francesco Forconi,Luca Laurenti,Roberto Marasca,Michele Dal-Bo,Francesca Rossi,Pietro Bulian,Josep F. Nomdedeu,Giovanni Del Poeta,Valter Gattei,Laura Pasqualucci,Laura Pasqualucci,Raul Rabadan,Robin Foà,Riccardo Dalla-Favera,Gianluca Gaidano +25 more
TL;DR: This integrated mutational and cytogenetic model independently predicted survival, improved CLL prognostication accuracy compared with FISH karyotype, and was externally validated in an independent CLL cohort.
Journal ArticleDOI
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
Davide Rossi,Silvia Rasi,Giulia Fabbri,Valeria Spina,Marco Fangazio,Francesco Forconi,Roberto Marasca,Luca Laurenti,Alessio Bruscaggin,Michaela Cerri,Sara Monti,Stefania Cresta,Rosella Famà,Lorenzo De Paoli,Pietro Bulian,Valter Gattei,Anna Guarini,Silvia Deaglio,Daniela Capello,Raul Rabadan,Laura Pasqualucci,Riccardo Dalla-Favera,Robin Foà,Gianluca Gaidano +23 more
TL;DR: NotCH1 mutations are an independent predictor of CLL OS, tend to be mutually exclusive with TP53 abnormalities, and identify cases with a dismal prognosis, which is attributable to shorter treatment-free survival and higher risk of Richter transformation.
Journal ArticleDOI
The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
Davide Rossi,Vladimir Trifonov,Marco Fangazio,Alessio Bruscaggin,Silvia Rasi,Valeria Spina,Sara Monti,Tiziana Vaisitti,Francesca Arruga,Rosella Famà,Carmela Ciardullo,Mariangela Greco,Stefania Cresta,Daniela Piranda,Antony B. Holmes,Giulia Fabbri,Monica Messina,Andrea Rinaldi,Jiguang Wang,Claudio Agostinelli,Pier Paolo Piccaluga,Marco Lucioni,Fabrizio Tabbò,Roberto Serra,Silvia Franceschetti,Clara Deambrogi,Giulia Daniele,Valter Gattei,Roberto Marasca,Fabio Facchetti,Luca Arcaini,Giorgio Inghirami,Francesco Bertoni,Stefano Pileri,Silvia Deaglio,Robin Foà,Riccardo Dalla-Favera,Laura Pasqualucci,Raul Rabadan,Gianluca Gaidano +39 more
TL;DR: Notch2 mutations represent the most frequent lesion in splenic marginal zone lymphoma and are associated with atypical granuloma-like lesions.
Journal ArticleDOI
The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
Davide Rossi,Valeria Spina,Clara Deambrogi,Silvia Rasi,Luca Laurenti,Kostas Stamatopoulos,Luca Arcaini,Marco Lucioni,Gabrielle B. Rocque,Zijun Y. Xu-Monette,Carlo Visco,Julie Chang,Ekaterina Chigrinova,Francesco Forconi,Roberto Marasca,Caroline Besson,Theodora Papadaki,Marco Paulli,Luigi Maria Larocca,Stefano Pileri,Valter Gattei,Francesco Bertoni,Robin Foà,Ken H. Young,Gianluca Gaidano +24 more
TL;DR: The molecular dissection of RS into biologically distinct categories highlights the genetic heterogeneity of this disorder and provides clinically relevant information for refining the prognostic stratification of patients.