J
Juhye Kang
Researcher at KAIST
Publications - 26
Citations - 1067
Juhye Kang is an academic researcher from KAIST. The author has contributed to research in topics: Medicine & Protein aggregation. The author has an hindex of 12, co-authored 23 publications receiving 711 citations. Previous affiliations of Juhye Kang include Pohang University of Science and Technology & Ulsan National Institute of Science and Technology.
Papers
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Journal ArticleDOI
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
Masha G. Savelieff,Geewoo Nam,Geewoo Nam,Juhye Kang,Juhye Kang,Hyuck Jin Lee,Misun Lee,Misun Lee,Mi Hee Lim +8 more
TL;DR: Possible therapeutic targets in Alzheimer's disease, Parkinson's Disease, and amyotrophic lateral sclerosis are outlined and molecules, previously designed or discovered as potential drug candidates for these disorders with emphasis on multifunctionality are discussed.
Journal ArticleDOI
Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
Jung Seung Nam,Myeong-Gyun Kang,Juhye Kang,Sunyoung Park,Shin Jung C. Lee,Hyun-Tak Kim,Jeong Kon Seo,Oh-Hoon Kwon,Mi Hee Lim,Hyun-Woo Rhee,Tae-Hyuk Kwon +10 more
TL;DR: The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation because of the relatively high (1)O2 quantum yield (> 0.78), even with two-photon activation.
Journal ArticleDOI
Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer's Disease.
Eunju Nam,Eunju Nam,Jeffrey S. Derrick,Seung-Hee Lee,Juhye Kang,Juhye Kang,Jiyeon Han,Shin Jung C. Lee,Su Wol Chung,Mi Hee Lim +9 more
TL;DR: It is reported that DA and its rationally designed structural derivatives based on DA's oxidative transformation are able to modulate multiple pathological elements found in AD with demonstration of detailed molecular-level mechanisms.
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Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides
Jeffrey S. Derrick,Jiwan Lee,Shin Jung C. Lee,Yujeong Kim,Eunju Nam,Hyeonwoo Tak,Juhye Kang,Misun Lee,Sun Hee Kim,Kiyoung Park,Jaeheung Cho,Mi Hee Lim +11 more
TL;DR: A novel approach to validate the hydrolytic cleavage of divalent metal complexes toward two major isoforms of Aβ and tune their proteolytic activity based on the choice of metal centers which could be correlated to their anti-amyloidogenic properties is reported.
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Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation.
TL;DR: A greater understanding of how transition metal complexes have been engineered and used for alteration of Aβ aggregation could provide insight into the new discovery of chemical reagents against Aβ peptides found in AD.