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Misun Lee

Researcher at Ulsan National Institute of Science and Technology

Publications -  9
Citations -  453

Misun Lee is an academic researcher from Ulsan National Institute of Science and Technology. The author has contributed to research in topics: Prodrug & Reactivity (chemistry). The author has an hindex of 5, co-authored 8 publications receiving 282 citations. Previous affiliations of Misun Lee include KAIST.

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Journal ArticleDOI

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Masha G. Savelieff, +8 more
- 23 Jan 2019 - 
TL;DR: Possible therapeutic targets in Alzheimer's disease, Parkinson's Disease, and amyotrophic lateral sclerosis are outlined and molecules, previously designed or discovered as potential drug candidates for these disorders with emphasis on multifunctionality are discussed.
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Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides

Jeffrey S. Derrick, +11 more
- 18 Jan 2017 - 
TL;DR: A novel approach to validate the hydrolytic cleavage of divalent metal complexes toward two major isoforms of Aβ and tune their proteolytic activity based on the choice of metal centers which could be correlated to their anti-amyloidogenic properties is reported.
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N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice

Min Hee Park, +21 more
- 19 Nov 2019 - 
TL;DR: The in vitro and in vivo investigations on efficacies and molecular-level mechanisms demonstrate the ability of DAPPD to regulate microglial function, suppress neuroinflammation, foster cerebral Aβ clearance, and attenuate cognitive deficits in AD transgenic mouse models.
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Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia.

Mingeun Kim, +20 more
- 01 Apr 2020 - 
TL;DR: The studies demonstrate an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents and significantly attenuates the amyloid pathology in the brains of AD transgenic mice and improves their cognitive defects.
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A near-infrared fluorescent probe for amyloid-β aggregates

Misun Lee, +8 more
- 01 Mar 2019 - 
TL;DR: A turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety and is nontoxic under the condition used for live-cell imaging.