J
Julia Hartmann
Researcher at University of Düsseldorf
Publications - 7
Citations - 76
Julia Hartmann is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications receiving 23 citations.
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Journal ArticleDOI
Stem Cells for Next Level Toxicity Testing in the 21st Century.
Ellen Fritsche,Thomas Haarmann-Stemmann,Julia Kapr,Saskia Galanjuk,Julia Hartmann,Peter R. Mertens,Angela A. M. Kämpfer,Roel P.F. Schins,Julia Tigges,Katharina Koch +9 more
TL;DR: In this paper, most critical organs for toxicity assessment, i.e., skin, brain, thyroid system, lung, heart, liver, kidney, and intestine are discussed with regards to their functions in health and disease.
Journal ArticleDOI
Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation.
Laura Nimtz,Julia Hartmann,Julia Tigges,Stefan Masjosthusmann,Martin Schmuck,Eike Keßel,Stephan Theiss,Karl Köhrer,Patrick Petzsch,James Adjaye,Claudia Wigmann,Dagmar Wieczorek,Barbara Hildebrandt,Farina Bendt,Ulrike Hübenthal,Gabriele Brockerhoff,Ellen Fritsche +16 more
TL;DR: Human NN (hNN) is established and characterized from hiPSC-derived neural progenitor cells by comparing hNN formation with two different differentiation media: in presence (CINDA) and absence (neural differentiation medium (NDM)) of maturation-supporting factors.
Book ChapterDOI
Neural In Vitro Models for Studying Substances Acting on the Central Nervous System
Ellen Fritsche,Julia Tigges,Julia Hartmann,Julia Kapr,Melania Maria Serafini,Barbara Viviani +5 more
TL;DR: This chapter gives an overview over stem cell-based human 2D neuronal and mixed neuronal/astrocyte models, in vitro cultures of microglia, as well as CNS disease models and considers new developments in the field, more specifically the use of brain organoids and 3D bioprinted in vitro models for safety and efficacy evaluation.
Journal ArticleDOI
Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
Katharina Koch,Kristina Bartmann,Julia Hartmann,Julia Kapr,Jördis Klose,Eliška Kuchovská,Melanie Pahl,K. Schlüppmann,Etta Zühr,Ellen Fritsche +9 more
TL;DR: This study scientifically validate the Neurosphere Assay, which is based on human primary neural progenitor cells (hNPCs) and an integral part of the DNT in vitro screening battery is well poised for DNT evaluation for regulatory purposes.