J
Julian A. Abrams
Researcher at Columbia University
Publications - 171
Citations - 6471
Julian A. Abrams is an academic researcher from Columbia University. The author has contributed to research in topics: Barrett's esophagus & Cancer. The author has an hindex of 38, co-authored 148 publications receiving 5295 citations. Previous affiliations of Julian A. Abrams include Columbia University Medical Center & NewYork–Presbyterian Hospital.
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Journal ArticleDOI
Proton pump inhibitors alter the composition of the gut microbiota
Matthew A. Jackson,Julia K. Goodrich,Maria Emanuela Maxan,Daniel E. Freedberg,Julian A. Abrams,Angela C. Poole,Jessica L. Sutter,Daphne K. Welter,Ruth E. Ley,Jordana T. Bell,Tim D. Spector,Claire J. Steves +11 more
TL;DR: A significant impact of PPIs on the gut microbiome is described and should caution over-use ofPPIs, and the observed changes result from the removal of the low pH barrier between upper GI tract bacteria and the lower gut.
Journal ArticleDOI
Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia
Michael Quante,Michael Quante,Govind Bhagat,Julian A. Abrams,Frederic Marache,Pamela Good,Michele D. Lee,Yoomi Lee,Richard A. Friedman,Samuel Asfaha,Zinaida A. Dubeykovskaya,Umar Mahmood,Jose-Luiz Figueiredo,Jan Kitajewski,Carrie J. Shawber,Charles J. Lightdale,Anil K. Rustgi,Timothy C. Wang +17 more
TL;DR: The data suggest that BE and EAC arise from gastric progenitors due to a tumor-promoting IL-1β-IL-6 signaling cascade and Dll1-dependent Notch signaling.
Journal ArticleDOI
Adherence to Biopsy Guidelines for Barrett's Esophagus Surveillance in the Community Setting in the United States
Julian A. Abrams,Robert C. Kapel,Guy M. Lindberg,Mohammad H. Saboorian,Robert M. Genta,Robert M. Genta,Alfred I. Neugut,Charles J. Lightdale +7 more
TL;DR: Adherence to BE biopsy guidelines in the community is low, and nonadherence is associated with significantly decreased dysplasia detection, according to a national community-based pathology database.
Journal ArticleDOI
Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer
Reem Z. Sharaiha,Karim J. Halazun,Farooq Mirza,Jeffrey L. Port,Paul C. Lee,Alfred I. Neugut,Alfred I. Neugut,Nasser K. Altorki,Nasser K. Altorki,Julian A. Abrams,Julian A. Abrams +10 more
TL;DR: Preoperative NLR is a potential prognostic marker for recurrence and death after esophagectomy and it is unclear whether NLR reflects the degree of inflammatory response to the primary tumor or other patient-specific or tumor characteristics that predispose to recurrence.
Journal ArticleDOI
Real-time increased detection of neoplastic tissue in Barrett's esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial
Prateek Sharma,A Meining,Emmanuel Coron,Charles J. Lightdale,Herbert C. Wolfsen,Ajay Bansal,Monther Bajbouj,Jean Paul Galmiche,Julian A. Abrams,Amit Rastogi,Neil Gupta,Joel E. Michalek,Gregory Y. Lauwers,Michael B. Wallace +13 more
TL;DR: In this paper, the authors compared the sensitivity and specificity of probe-based confocal laser endomicroscopy (pCLE) with HD-WLE alone for the detection of high-grade dysplasia (HGD) and early carcinoma (EC) in BE.