J
Jordana T. Bell
Researcher at King's College London
Publications - 194
Citations - 21849
Jordana T. Bell is an academic researcher from King's College London. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 58, co-authored 177 publications receiving 16148 citations. Previous affiliations of Jordana T. Bell include Guy's and St Thomas' NHS Foundation Trust & Erasmus University Rotterdam.
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Journal ArticleDOI
Human Genetics Shape the Gut Microbiome
Julia K. Goodrich,Jillian L. Waters,Angela C. Poole,Jessica L. Sutter,Omry Koren,Ran Blekhman,Michelle Beaumont,Will Van Treuren,Rob Knight,Rob Knight,Jordana T. Bell,Tim D. Spector,Andrew G. Clark,Ruth E. Ley +13 more
TL;DR: Compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, many microbial taxa whose abundances were influenced by host genetics were identified.
Journal ArticleDOI
Mapping cis - and trans -regulatory effects across multiple tissues in twins
Elin Grundberg,Kerrin S. Small,Kerrin S. Small,Åsa K. Hedman,Alexandra C. Nica,Alfonso Buil,Sarah Keildson,Jordana T. Bell,Jordana T. Bell,Yang T-P.,Eshwar Meduri,Eshwar Meduri,Amy Barrett,James Nisbett,Magdalena Sekowska,Alicja Wilk,Shin S-Y.,Daniel Glass,Mary E. Travers,Josine L. Min,Susan M. Ring,Karen M Ho,Gudmar Thorleifsson,Augustine Kong,Unnur Thorsteindottir,Unnur Thorsteindottir,Chrysanthi Ainali,Antigone S. Dimas,Neelam Hassanali,Catherine E. Ingle,David A. Knowles,Maria Krestyaninova,Christopher E. Lowe,Christopher E. Lowe,P. Di Meglio,Stephen B. Montgomery,Stephen B. Montgomery,Leopold Parts,Simon C. Potter,Gabriela L. Surdulescu,Loukia Tsaprouni,Sophia Tsoka,Veronique Bataille,Richard Durbin,Frank O. Nestle,Stephen O'Rahilly,Stephen O'Rahilly,Nicole Soranzo,Cecilia M. Lindgren,Krina T. Zondervan,Kourosh R. Ahmadi,Eric E. Schadt,Kari Stefansson,Kari Stefansson,George Davey Smith,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Panos Deloukas,Emmanouil T. Dermitzakis,Tim D. Spector +60 more
TL;DR: It is shown that at least 40% of the total heritable cis effect on expression cannot be accounted for by common cis variants, a finding that reveals the contribution of low-frequency and rare regulatory variants with respect to both transcriptional regulation and complex trait susceptibility.
Journal ArticleDOI
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Journal ArticleDOI
Genetic Determinants of the Gut Microbiome in UK Twins
Julia K. Goodrich,Emily R. Davenport,Michelle Beaumont,Matthew A. Jackson,Rob Knight,Carole Ober,Tim D. Spector,Jordana T. Bell,Andrew G. Clark,Ruth E. Ley,Ruth E. Ley +10 more
TL;DR: The results indicate that diet-sensing, metabolism, and immune defense are important drivers of human-microbiome co-evolution.
Journal ArticleDOI
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines.
Jordana T. Bell,Jordana T. Bell,Athma A. Pai,Joseph K. Pickrell,Daniel J. Gaffney,Daniel J. Gaffney,Roger Pique-Regi,Jacob F. Degner,Yoav Gilad,Jonathan K. Pritchard,Jonathan K. Pritchard +10 more
TL;DR: A strong genetic component to inter-individual variation in DNA methylation profiles is demonstrated, and there was an enrichment of SNPs that affect both methylation and gene expression, providing evidence for shared mechanisms in a fraction of genes.