Z
Zinaida A. Dubeykovskaya
Researcher at Columbia University Medical Center
Publications - 14
Citations - 1319
Zinaida A. Dubeykovskaya is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Helicobacter felis & Receptor. The author has an hindex of 10, co-authored 12 publications receiving 1069 citations. Previous affiliations of Zinaida A. Dubeykovskaya include Columbia University.
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Journal ArticleDOI
Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia
Michael Quante,Michael Quante,Govind Bhagat,Julian A. Abrams,Frederic Marache,Pamela Good,Michele D. Lee,Yoomi Lee,Richard A. Friedman,Samuel Asfaha,Zinaida A. Dubeykovskaya,Umar Mahmood,Jose-Luiz Figueiredo,Jan Kitajewski,Carrie J. Shawber,Charles J. Lightdale,Anil K. Rustgi,Timothy C. Wang +17 more
TL;DR: The data suggest that BE and EAC arise from gastric progenitors due to a tumor-promoting IL-1β-IL-6 signaling cascade and Dll1-dependent Notch signaling.
Journal ArticleDOI
Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling
Yoku Hayakawa,Yoku Hayakawa,Kosuke Sakitani,Mitsuru Konishi,Samuel Asfaha,Samuel Asfaha,Ryota Niikura,Hiroyuki Tomita,Bernhard W. Renz,Bernhard W. Renz,Yagnesh Tailor,Marina Macchini,Moritz Middelhoff,Zhengyu Jiang,Takayuki Tanaka,Zinaida A. Dubeykovskaya,Woosook Kim,Xiaowei Chen,Aleksandra M. Urbanska,Karan Nagar,Christoph B. Westphalen,Christoph B. Westphalen,Michael Quante,Chyuan Sheng Lin,Michael D. Gershon,Akira Hara,Chun-Mei Zhao,Duan Chen,Daniel L. Worthley,Daniel L. Worthley,Kazuhiko Koike,Timothy C. Wang +31 more
TL;DR: It is found that Dclk1+ tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa and this feedforward ACh-NGF axis activates the Gastric cancer niche and offers a compelling target for tumor treatment and prevention.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang,Zeli Shen,James G. Fox +29 more
TL;DR: In this article, the authors proposed a new method for cancer drug discovery based on protein-protein interactions, and obtained grants from the National Institutes of Health (U.S.) (Grants 54CA126513, R01CA093405, R1CA120979, and R1DK052778).
Journal ArticleDOI
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Samuel Asfaha,Alexander Dubeykovskiy,Hiroyuki Tomita,Xiangdong Yang,Sarah Stokes,Wataru Shibata,Richard A. Friedman,Hiroshi Ariyama,Zinaida A. Dubeykovskaya,Sureshkumar Muthupalani,Russell Ericksen,Harold Frucht,James G. Fox,Timothy C. Wang +13 more
TL;DR: IL-8 contributes to gastrointestinal carcinogenesis by mobilizing IMCs and might be a therapeutic target for gastrointestinal cancers.
Journal ArticleDOI
Secreted Trefoil Factor 2 Activates the CXCR4 Receptor in Epithelial and Lymphocytic Cancer Cell Lines
TL;DR: Overall these data identify CXCR4 as a bona fide signaling receptor for TFF2 and suggest a mechanism through which TFF 2 may modulate immune and tumorigenic responses in vivo.