J
Julie A. Mangada
Researcher at University of Massachusetts Medical School
Publications - 5
Citations - 1645
Julie A. Mangada is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Haematopoiesis & Myeloid. The author has an hindex of 5, co-authored 5 publications receiving 1465 citations.
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Journal ArticleDOI
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Leonard D. Shultz,Bonnie L. Lyons,Lisa M. Burzenski,Bruce Gott,Xiaohua Chen,Stanley Chaleff,Malak Kotb,Stephen D. Gillies,Marie King,Julie A. Mangada,Dale L. Greiner,Rupert Handgretinger +11 more
TL;DR: NOD-scid IL2Rγnull mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment.
Journal ArticleDOI
Rapid quantification of naive alloreactive T cells by TNF-α production and correlation with allograft rejection in mice
Michael A. Brehm,Julie A. Mangada,Thomas G. Markees,Todd Pearson,Keith A. Daniels,Thomas B. Thornley,Raymond M. Welsh,Aldo A. Rossini,Dale L. Greiner +8 more
TL;DR: Rapid production of TNF-alpha can be used to quantify naive alloreactive T cells, it is abrogated after the induction of tolerance, and it is a potential tool to predict allograft rejection.
Journal ArticleDOI
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Masahiro Yamazaki,Todd Pearson,Michael A. Brehm,David Miller,Julie A. Mangada,Thomas G. Markees,Leonard D. Shultz,John P. Mordes,Aldo A. Rossini,Dale L. Greiner +9 more
TL;DR: It is shown that costimulation blockade using a donor‐specific transfusion and anti‐CD154 antibody applied to mice given bone marrow and simultaneously transplanted with skin allografts leads to hematopoietic chimerism and permanent skinAllograft survival.
Journal ArticleDOI
Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
Julie A. Mangada,Todd Pearson,Michael A. Brehm,Linda S. Wicker,Laurence B. Peterson,Leonard D. Shultz,David V. Serreze,Aldo A. Rossini,Dale L. Greiner +8 more
TL;DR: The data suggest that Idd loci can facilitate induction of transplantation tolerance by costimulation blockade and that IL-2/Idd3 is a critical component in this process.
This information is current as Hemopoietic Stem Cells Mice Engrafted with Mobilized Human null γ Development in NOD/LtSz-scid IL2R Human Lymphoid and Myeloid Cell
Rupert Handgretinger,Stephen D. Gillies,Julie A. Mangada,Xiaohua Chen,Stanley Chaleff,Malak Kotb,Leonard D. Shultz,Bonnie L. Lyons,Lisa M. Burzenski +8 more