L
Laurence B. Peterson
Researcher at Merck & Co.
Publications - 107
Citations - 10111
Laurence B. Peterson is an academic researcher from Merck & Co.. The author has contributed to research in topics: NOD mice & Congenic. The author has an hindex of 51, co-authored 107 publications receiving 9805 citations. Previous affiliations of Laurence B. Peterson include University of Cambridge & John Radcliffe Hospital.
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Journal ArticleDOI
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda,Howson Jmm.,Laura Esposito,Joanne M. Heward,Hywel Snook,Giselle Chamberlain,Dan Rainbow,Hunter Kmd.,Anne Smith,G Di Genova,G Di Genova,Mathias H. Herr,Mathias H. Herr,Ingrid Dahlman,Ingrid Dahlman,F Payne,Deborah J. Smyth,Christopher E. Lowe,Twells Rcj.,Sarah Howlett,Barry C. Healy,Sarah Nutland,Helen E. Rance,Vincent H. Everett,Luc J. Smink,A C Lam,Heather J. Cordell,Neil Walker,C Bordin,John S. Hulme,Costantino Motzo,Francesco Cucca,J F Hess,Michael L. Metzker,Michael L. Metzker,Jane Rogers,Simon G. Gregory,Amit Allahabadia,Amit Allahabadia,R Nithiyananthan,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Polly J. Bingley,Kathleen M Gillespie,Dag E. Undlien,Kjersti S. Rønningen,Cristian Guja,Constantin Ionescu-Tirgoviste,David A. Savage,Alexander P. Maxwell,Dennis Carson,Christopher Patterson,Jayne A. Franklyn,David Clayton,Laurence B. Peterson,Linda S. Wicker,John A. Todd,Gough Scl. +57 more
TL;DR: In this article, the authors identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4) as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes.
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Genetic Control of Autoimmune Diabetes in the Nod Mouse
TL;DR: While only partial protection from disease is provided by resistance alleles at single non-MHC Idd loci, epistatic interaction between two of the loci produced nearly complete protection from diabetes.
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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Jun Yamanouchi,Dan Rainbow,Pau Serra,Sarah Howlett,Kara Hunter,Valerie E S Garner,Andrea Gonzalez-Munoz,Jan Clark,Riitta Veijola,Rose M. Cubbon,Show-Ling Chen,Ray Rosa,Anne Marie Cumiskey,David V. Serreze,Simon G. Gregory,Jane Rogers,Paul A. Lyons,Barry C. Healy,Luc J. Smink,John A. Todd,Laurence B. Peterson,Linda S. Wicker,Pere Santamaria +22 more
TL;DR: It is shown that engineered haplodeficiency of Il2 gene expression not only reduces T cell IL-2 production by twofold but also mimics the autoimmune dysregulatory effects of the naturally occurring susceptibility alleles of Il1.
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Polygenic control of autoimmune diabetes in nonobese diabetic mice
S Ghosh,S M Palmer,N R Rodrigues,Heather J. Cordell,C M Hearne,Richard J. Cornall,Jan-Bas Prins,McShane P,G.M. Lathrop,Laurence B. Peterson +9 more
TL;DR: Evidence of linkage of ten distinct loci to diabetes or the pre–diabetic lesion, insulitis, indicative of a polygenic mode of inheritance is obtained and a new application of multiple polychotomous regression methods is assessed.
Journal ArticleDOI
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
Linda S. Wicker,Edward H. Leiter,John A. Todd,Robert J Renjilian,Erin Peterson,Paul A. Fischer,Patricia L Podolin,Maarten Zijlstra,Rudolf Jaenisch,Laurence B. Peterson +9 more
TL;DR: It is demonstrated that NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis.