L
Linda S. Wicker
Researcher at University of Cambridge
Publications - 177
Citations - 15676
Linda S. Wicker is an academic researcher from University of Cambridge. The author has contributed to research in topics: NOD mice & Nod. The author has an hindex of 59, co-authored 169 publications receiving 15002 citations. Previous affiliations of Linda S. Wicker include Merck & Co. & University of Oxford.
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Journal ArticleDOI
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda,Howson Jmm.,Laura Esposito,Joanne M. Heward,Hywel Snook,Giselle Chamberlain,Dan Rainbow,Hunter Kmd.,Anne Smith,G Di Genova,G Di Genova,Mathias H. Herr,Mathias H. Herr,Ingrid Dahlman,Ingrid Dahlman,F Payne,Deborah J. Smyth,Christopher E. Lowe,Twells Rcj.,Sarah Howlett,Barry C. Healy,Sarah Nutland,Helen E. Rance,Vincent H. Everett,Luc J. Smink,A C Lam,Heather J. Cordell,Neil Walker,C Bordin,John S. Hulme,Costantino Motzo,Francesco Cucca,J F Hess,Michael L. Metzker,Michael L. Metzker,Jane Rogers,Simon G. Gregory,Amit Allahabadia,Amit Allahabadia,R Nithiyananthan,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Polly J. Bingley,Kathleen M Gillespie,Dag E. Undlien,Kjersti S. Rønningen,Cristian Guja,Constantin Ionescu-Tirgoviste,David A. Savage,Alexander P. Maxwell,Dennis Carson,Christopher Patterson,Jayne A. Franklyn,David Clayton,Laurence B. Peterson,Linda S. Wicker,John A. Todd,Gough Scl. +57 more
TL;DR: In this article, the authors identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4) as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes.
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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Genetic Control of Autoimmune Diabetes in the Nod Mouse
TL;DR: While only partial protection from disease is provided by resistance alleles at single non-MHC Idd loci, epistatic interaction between two of the loci produced nearly complete protection from diabetes.
Journal Article
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
TL;DR: It is demonstrated that the induction of diabetes in the adoptive transfer system is dependent on both the L3T4+ and Lyt-2+ subsets of T cells, and that neither subset can be replaced with cells obtained from young, nondiabetic donors.
Journal ArticleDOI
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E. Lowe,Jason D. Cooper,Todd M. Brusko,Neil Walker,Deborah J. Smyth,Rebecca Bailey,Kirsi Bourget,Vincent Plagnol,Sarah F. Field,Mark A. Atkinson,David Clayton,Linda S. Wicker,John A. Todd +12 more
TL;DR: The type 1 diabetes (T1D) association in the interleukin 2 receptor alpha (IL2RA) gene region is localized to two independent groups of SNPs, spanning overlapping regions of 14 and 40 kb, encompassing IL2RA intron 1 and the 5′ regions of IL2 RA and RBM17.