Julie E. Baggs

TL;DR: These studies illustrate the importance of time sampling with respect to multiple testing, suggest caution in use of autonomous cellular models to study clock output, and demonstrate the existence of harmonics of circadian gene expression in the mouse.

TL;DR: It is demonstrated that CRY-mediated repression of the CLOCK/BMAL1 complex activity is required for maintenance of circadian rhythmicity and formal proof that transcriptional feedback is requiredFor mammalian clock function is provided.

TL;DR: It was found that asparagine was necessary and sufficient to suppress glutamine-withdrawal-induced apoptosis without restoring the levels of other nonessential amino acids or TCA cycle intermediates.

TL;DR: This work developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA-induced dose-dependent changes in gene expression were used to build gene association networks consistent with known biochemical constraints, and uncovered several novel network features of the circadian clock, including proportional responses and signal propagation through interacting genetic modules.

TL;DR: Two independent studies, one of them using a computational approach, identified CHRONO, a gene shown to modulate the activity of circadian transcription factors and alter circadian behavior in mice.