Juliette M. K. M. Delhove

TL;DR: A lentiviral reporter system is developed to assay longitudinal changes in cell signaling and transcription factor activity in living cells throughout iPSC reprogramming of human dermal fibroblasts and shows that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which initiates the HIFα-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway.

TL;DR: In this article, microRNA expression profiles have been associated with sporadic pituitary adenomas, suggesting that miRNAs can contribute to tumor formation; microRNAs are small noncoding RN...

TL;DR: In this article, the authors discuss the need for patient and public support for gene therapy and gene editing technologies in order to understand their possible benefits or side effects and their potential side effects.

TL;DR: This work presents a novel approach of tissue-targeted delivery of transcription factor activated luciferase reporter lentiviruses to neonatal rodents as an alternative to the existing technology of generating germline transgenic light producing rodents and shows the malleability of this technology by quantifying NFκB-mediatedLuciferase expression in outbred rats.

TL;DR: BMI-1 delayed senescence in bronchial epithelial cells, increasing their proliferative potential but maintaining mucociliary differentiation at ALI, has shown these cells are amenable to genetic manipulation and can be used to produce novel disease models for research and dissemination.