Vassilios N. Kotiadis

TL;DR: The generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including induced pluripoline stem cells (iPSCs) from patients with Duchenne, limb-girdle, and congenital muscular dystrophies is reported.

TL;DR: The synergistic mechanisms that control mitochondrial quality and function and ensure cellular bioenergetic homeostasis are explored, including antioxidant defence mechanisms that protect against oxidative damage caused by reactive oxygen species, while regulating signals transduced through such free radicals.

TL;DR: A lentiviral reporter system is developed to assay longitudinal changes in cell signaling and transcription factor activity in living cells throughout iPSC reprogramming of human dermal fibroblasts and shows that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which initiates the HIFα-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway.

TL;DR: It is shown that protein CoAlation is a reversible post-translational modification that is induced in mammalian cells and tissues by oxidising agents and metabolic stress and may play an important role in redox regulation under physiological and pathophysiological conditions.

TL;DR: It is suggested that AMPK activation enriches, or leads to the emergence of, a population of subcutaneous white adipocytes that produce heat via Ucp1-independent uncoupling of adenosine triphosphate (ATP) production on a HFD.