J
Julius Brennecke
Researcher at Austrian Academy of Sciences
Publications - 63
Citations - 18767
Julius Brennecke is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 38, co-authored 59 publications receiving 17417 citations. Previous affiliations of Julius Brennecke include European Bioinformatics Institute & Howard Hughes Medical Institute.
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Principles of MicroRNA–Target Recognition
TL;DR: The minimal requirements for functional miRNA–target duplexes in vivo are evaluated and classes of target sites with different functional properties are distinguished, indicating that miRNAs regulate a large fraction of protein-coding genes and that miRNA 3′ ends are key determinants of target specificity within miRNA families.
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Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Julius Brennecke,Alexei A. Aravin,Alexander Stark,Monica Dus,Manolis Kellis,Ravi Sachidanandam,Gregory J. Hannon +6 more
TL;DR: Examination of piwi-interacting RNAs associated with each Drosophila Piwi protein finds that Piwi and Aubergine bind RNAs that are predominantly antisense to transposons, whereas Ago3 complexes contain predominantly sense piRNAs.
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bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
TL;DR: It is reported that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth and identifies the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-APoptotic activity.
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Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.
TL;DR: It is reported that a large set of genes involved in basic cellular processes avoid microRNA regulation due to short 3'UTRs that are specifically depleted of microRNA binding sites, ensuring tissue identity and supporting cell-lineage decisions.
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The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
TL;DR: As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history, and a likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.