J
Jun He
Researcher at Tianjin University of Traditional Chinese Medicine
Publications - 99
Citations - 2805
Jun He is an academic researcher from Tianjin University of Traditional Chinese Medicine. The author has contributed to research in topics: High-performance liquid chromatography & Cancer. The author has an hindex of 24, co-authored 96 publications receiving 2090 citations. Previous affiliations of Jun He include Thomas Jefferson University & Nanjing Medical University.
Papers
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Journal ArticleDOI
A validated LC-MS/MS method for determination of periplogenin in rat plasma and its application in pharmacokinetic study.
Fang Bo,Ting Dou,Xingrui Wang,Paul Owusu Donkor,Huizi Ouyang,Yan-xu Chang,Yaru Tu,Xiumei Gao,Jun He +8 more
TL;DR: The proposed method was successfully applied in evaluating the pharmacokinetics of periplogenin after an oral dose of 30mg/kg Cortex Periplocae extract in rats.
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Simultaneous determination of columbianetin-β-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β-d-glucopyranoside metabolites by ultra high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry.
TL;DR: It was found that CBG could be catabolized into its active metabolite CBN in vivo in vivo and the validated methods were successfully applied for absorption, distribution, metabolism and excretion study of CBG.
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The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection
TL;DR: A sensitive, specific, reproducible and optimized high performance liquid chromatography with fluorescence detection (HPLC-FLD) method for the determination of bergapten in rat plasma was established and applied to the pharmacokinetic and bioavailability study in rat after oral and intravenous administration of b Bergapten.
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An Established HPLC-MS/MS Method for Evaluation of the Influence of Salt Processing on Pharmacokinetics of Six Compounds in Cuscutae Semen
Jiao Liu,Shuhan Zou,Wei Liu,Jin Li,Hui Wang,Jiao Hao,Jun He,Xiumei Gao,Erwei Liu,Yan-xu Chang +9 more
TL;DR: The results indicated that salt processing could improve the adsorption and bioavailability of astragalin in Cuscutae Semen.
Journal ArticleDOI
S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.
Hua Shen,Gao-Chan Wang,Xiang Li,Xiang Li,Xin Ge,Meng Wang,Zhumei Shi,Vikas Bhardwaj,Zi-Xuan Wang,Ralph Zinner,Stephen C. Peiper,Andrew E. Aplin,Bing-Hua Jiang,Jun He +13 more
TL;DR: Evidence is presented for the reversal of resistance to EGFR TKI by the addition of small molecule S6K1/MDM2 antagonists that could have clinical benefit.