J
Jun Igarashi
Researcher at Nihon University
Publications - 17
Citations - 576
Jun Igarashi is an academic researcher from Nihon University. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 11, co-authored 17 publications receiving 540 citations. Previous affiliations of Jun Igarashi include Roswell Park Cancer Institute.
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Journal ArticleDOI
Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
Ping Liang,Fei Song,Srimoyee Ghosh,Srimoyee Ghosh,Evan Morien,Evan Morien,Maochun Qin,Saleh Mahmood,Saleh Mahmood,Kyoko Fujiwara,Kyoko Fujiwara,Jun Igarashi,Hiroki Nagase,Hiroki Nagase,William A. Held +14 more
TL;DR: The data suggests the vast majority of unique sequence DNA methylation has tissue specificity, that demethylation has a prominent role in tissue differentiation, and that DNAmethylation has regulatory roles in alternative promoter selection and in non-promoter regions.
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Analysis of tissue-specific differentially methylated regions (TDMs) in humans.
Eiko Kitamura,Jun Igarashi,Aiko Morohashi,Naoko Hida,Toshinori Oinuma,Norimichi Nemoto,Fei Song,Srimoyee Ghosh,William A. Held,Chikako Yoshida-Noro,Hiroki Nagase,Hiroki Nagase +11 more
TL;DR: It is indicated that some genomic regions with tissue-specific methylation and expression are conserved between mouse and human and suggest that DNA methylation may have an important role in regulating differentiation and tissue-/cell-specific gene expression of some genes.
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Inhibition of MMP‐9 transcription and suppression of tumor metastasis by pyrrole‐imidazole polyamide
Xiaofei Wang,Hiroki Nagase,Hiroki Nagase,Takayoshi Watanabe,Hiroyuki Nobusue,Tsukasa Suzuki,Yukihiro Asami,Yui Shinojima,Hiroyuki Kawashima,Keiko Takagi,Rajeev Mishra,Jun Igarashi,Makoto Kimura,Tadatoshi Takayama,Noboru Fukuda,Hiroshi Sugiyama +15 more
TL;DR: A pyrrole-imidazole (PI) polyamide that targets the activator protein-1 (AP-1)-binding site of the MMP-9 promoter was designed and synthesized as a gene-silencing agent for tumor metastases as mentioned in this paper.
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Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas.
Haruhiko Okada,Makoto T. Kimura,Dongfeng Tan,Kyoko Fujiwara,Jun Igarashi,Masatoshi Makuuchi,Ai Min Hui,Masahiko Tsurumaru,Hiroki Nagase +8 more
TL;DR: The results indicate that TFF3 overexpression may be a critical process in mouse and human hepatocellular carcinogenesis, and the specific promoter CpG hypomethylation may be one of the regulation mechanisms of T FF3 overeexpression in HCCs.
Journal ArticleDOI
Quantitative analysis of human tissue-specific differences in methylation
Jun Igarashi,Satomi Muroi,Hiroyuki Kawashima,Xiaofei Wang,Yui Shinojima,Eiko Kitamura,Toshinori Oinuma,Norimichi Nemoto,Fei Song,Srimoyee Ghosh,William A. Held,Hiroki Nagase,Hiroki Nagase +12 more
TL;DR: DNA methylation levels of five testis-specific DMRs were significantly inversely correlated with the number of spermatocytes, but a positive correlation was seen at tDMRs located near the TRIM38 and CASZ1 genes.