J
Jun-Pil Jang
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 35
Citations - 548
Jun-Pil Jang is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Streptomyces & Medicine. The author has an hindex of 11, co-authored 29 publications receiving 437 citations. Previous affiliations of Jun-Pil Jang include Chosun University.
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Journal ArticleDOI
Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
Jae-Hyuk Jang,Yukihiro Asami,Jun-Pil Jang,Su N.Ok Kim,Dong Oh Moon,Kee-Sun Shin,Daisuke Hashizume,Makoto Muroi,Tamio Saito,Hyuncheol Oh,Bo Yeon Kim,Hiroyuki Osada,Jong Seog Ahn +12 more
TL;DR: An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar Morphogenesis assay system.
Journal ArticleDOI
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.
MinKyun Na,Jun-Pil Jang,Dieudonné Njamen,Joseph Tanyi Mbafor,Zacharias Tanee Fomum,Bo Yeon Kim,Won Keun Oh,Jong Seog Ahn +7 more
TL;DR: Bioassay-guided fractionation of an EtOAc-soluble extract of the root bark of Erythrina mildbraedii, using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new isoprenylated flavonoids, abyssinone-IV-4'-O-methyl ether, which may be considered as a new class of P TP1B inhibitors.
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Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
MinKyun Na,Jun-Pil Jang,Byung Sun Min,Lee Sang Jun,Myung Sun Lee,Bo Yeon Kim,Won Keun Oh,Jong Seog Ahn +7 more
TL;DR: Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma resulted in the isolation of a series of acylphloroglucinol derivatives, which could be considered to be a promising class of FAS inhibitors.
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PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens
Sohee Kim,MinKyun Na,Hyuncheol Oh,Jun-Pil Jang,Cheon Bae Sohn,Bo Yeon Kim,Won Keun Oh,Jong Seog Ahn +7 more
TL;DR: Kinetic studies suggest that both 1 and 2 are non-competitive inhibitors of PTP1B, however, compound 3 substituted with a hydroxyl group at C-17 in kaurane-type showed no inhibitory effects towards P TP1B.
Journal ArticleDOI
Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii
Jun-Pil Jang,MinKyun Na,Phuong Thien Thuong,Dieudonné Njamen,Joseph Tanyi Mbafor,Zacharias Tanee Fomum,Eun-Rhan Woo,Won Keun Oh +7 more
TL;DR: The isolates, except for compound 4, inhibited PTP1B activity in vitro with IC(50) values ranging from 5.3 to 42.6 microM, suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP 1B.