Jung H. Kim

TL;DR: This paper provides the first evidence of such reorganization of a hippocampal seizure focus in human temporal lobe epilepsy (TLE), which involves the selective loss of somatostatin and neuropeptide Y immunoreactive interneurons, and axonal sprouting of other neuropePTide Y neurons and dynorphin-A immunore active granule cells.

TL;DR: Sixty‐seven patients with temporal lobe epilepsy without circumscribed, potentially epileptogenic lesions, who were studied with intracranial electrodes and who became seizure free following temporal lobectomy were retrospectively evaluated with regard to preoperative scalp electroencephalographic (EEG) findings, neuropsychological test results, neuroimaging findings, results of surgery, and pathology of resected tissue.

TL;DR: MRI hippocampal measurements were compared to hippocampal neuronal densities obtained postoperatively and significant correlations existed between MRI measurements of the left hippocampus and the Wechsler logical memory percent retention scores and between the left temporal lobe measurements and the verbal Selective Reminding Test scores for patients with seizure foci in theleft temporal lobe.

TL;DR: Further studies are needed to define the cause of epileptic seizures in mesial temporal lobe epilepsy, but the loss of glutamine synthetase may provide a new focus for therapeutic interventions in MTLE.