J
Jürgen Markl
Researcher at University of Mainz
Publications - 100
Citations - 3905
Jürgen Markl is an academic researcher from University of Mainz. The author has contributed to research in topics: Hemocyanin & Megathura crenulata. The author has an hindex of 36, co-authored 100 publications receiving 3729 citations.
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Journal ArticleDOI
Keyhole limpet hemocyanin (KLH): a biomedical review.
J.R Harris,Jürgen Markl +1 more
TL;DR: This review presents a broad survey of fundamental scientific and medically applied studies on keyhole limpet hemocyanin (KLH) and gives a brief account of TEM studies on the native KLH oligomers, the experimental manipulation of the oligomeric states, together with immunolabelling data and studies on subunit reassociation.
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Structure of keyhole limpet hemocyanin type 1 (KLH1) at 15 A resolution by electron cryomicroscopy and angular reconstitution.
Elena V. Orlova,Elena V. Orlova,Prakash Dube,Prakash Dube,J. Robin Harris,Erich Beckman,F. Zemlin,Jürgen Markl,Marin van Heel +8 more
TL;DR: A three-dimensional reconstruction of keyhole limpet hemocyanin type 1 (KLH1) has been obtained using electron cryomicroscopy at liquid helium temperatures and single particle image processing, which shows much detail and reveals many new symmetry elements in this very large cylindrical molluscan hemOCyanin.
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Minireview: Recent progress in hemocyanin research.
TL;DR: It is shown that hemocyanins from species living at different environmental temperatures have a cooperativity optimum at the typical temperature of their natural habitat and the catalysis mechanism itself can now be explained on the basis of the recently published crystal structure of a tyrosinase.
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Evolution of molluscan hemocyanin structures.
TL;DR: Recent 3D reconstructions are used to explain and visualize the different functional units, subunits and quaternary structures of molluscan hemocyanins and their possible evolution is traced on the basis of DNA analyses and structural considerations.
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The sequence of a gastropod hemocyanin (HtH1 from Haliotis tuberculata).
TL;DR: Using the fossil record of the gastropod-cephalopod split to calibrate a molecular clock, the origin of the molluscan hemocyanin from a single-FU protein was calculated as 753 ± 68 million years ago, which fits recent paleontological evidence for the existence of rather large mollusc-like species in the late Precambrian.