J
Justin Hanes
Researcher at Johns Hopkins University
Publications - 298
Citations - 27850
Justin Hanes is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Drug delivery & Mucus. The author has an hindex of 75, co-authored 288 publications receiving 23760 citations. Previous affiliations of Justin Hanes include Massachusetts Institute of Technology & University of Alberta.
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Drugs and gene carrier particles that rapidly move through mucous barriers
TL;DR: In this article, the authors proposed a method for transporting bioactive agents across mucosal barriers by using polymeric particles suitable for transporting agents across the mucosal barrier, and they described methods of making and using those polymeric particle.
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Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo.
Katharina Maisel,Mihika Reddy,Qingguo Xu,Sumon Chattopadhyay,Sumon Chattopadhyay,Richard A. Cone,Richard A. Cone,Laura M. Ensign,Laura M. Ensign,Justin Hanes +9 more
TL;DR: It is demonstrated that by increasing the surface density, PEG with molecular weight (MW) as high as 40 kDa can be used as a mucoinert NP surface coating to prevent interactions with mucus.
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Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.
Justin Hanes,Allen K. Sills,Zhong Zhao,Kwang Wook Suh,Betty Tyler,Francesco DiMeco,Daniel J. Brat,Michael A. Choti,Kam W. Leong,Drew M. Pardoll,Henry Brem +10 more
TL;DR: Immunity memory was induced following IL-2 microsphere therapy in the B16-F10 brain tumor model that was capable of protecting 42% of animals from a subsequent intracranial tumor challenge, suggesting that tumor destruction was mediated by the immune system.
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Drug Absorption by the Respiratory Mucosa: Cell Culture Models and Particulate Drug Carriers
Carsten Ehrhardt,Jennifer Fiegel,Sabine Fuchs,Rana Abu-Dahab,Ulrich F. Schaefer,Justin Hanes,Claus M. Lehr +6 more
TL;DR: The inhalation route is of increasing interest for both local and systemic drug delivery, including macromolecular biopharmaceuticals, such as peptides, proteins, and gene therapeutics, and the effect and efficacy of novel drug carrier systems can be systematically studied.
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Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres
TL;DR: A close correlation between protein release and polymer weight loss was observed, suggesting a release mechanism controlled mainly by polymer erosion.