J
Justin Hanes
Researcher at Johns Hopkins University
Publications - 298
Citations - 27850
Justin Hanes is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Drug delivery & Mucus. The author has an hindex of 75, co-authored 288 publications receiving 23760 citations. Previous affiliations of Justin Hanes include Massachusetts Institute of Technology & University of Alberta.
Papers
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Journal ArticleDOI
Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth
Hannah C. Zierden,Hannah C. Zierden,Jairo Ortiz,Kevin DeLong,Jingqi Yu,Gaoshan Li,Gaoshan Li,Peter Dimitrion,Sabrine Bensouda,Victoria Laney,Victoria Laney,Anna Bailey,Nicole M. Anders,Morgan Scardina,Mala Mahendroo,Sam Mesiano,Irina Burd,Günter P. Wagner,Justin Hanes,Laura M. Ensign +19 more
TL;DR: In this article, the authors used a mouse model of intrauterine inflammation to test clinically used formulations, as well as engineered nano-formulations, for the prevention of preterm birth (PTB).
Journal ArticleDOI
Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery.
Fabiana Kashiwabuchi,Kunal S. Parikh,Revaz Omiadze,Shuming Zhang,Lixia Luo,Himatkumar V. Patel,Qingguo Xu,Laura M. Ensign,Hai-Quan Mao,Justin Hanes,Peter J. McDonnell +10 more
TL;DR: Wet electrospinning provides a suitable platform for the development of sutures that meet size requirements for ophthalmic surgery and are capable of sustained drug release; however, tensile strength must be improved prior to clinical use.
Patent
Mucus penetrating gene carriers
Jung Soo Suk,Justin Hanes +1 more
TL;DR: In this article, the authors described methods of making and using of nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (CF) mucus, as well as methods of using thereof, are described.
Journal ArticleDOI
Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
TL;DR: Evaluated rheological properties and drug or nanoparticle migration in hyaluronic acid - agar based hydrogels demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
Journal ArticleDOI
Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.
Kengyeh K. Chu,Diana Mojahed,Diana Mojahed,Courtney M. Fernandez,Yao Li,Linbo Liu,Eric J. Wilsterman,Bradford Diephuis,Susan E. Birket,Hannah L. Bowers,G. Martin Solomon,Benjamin S. Schuster,Justin Hanes,Steven M. Rowe,Guillermo J. Tearney +14 more
TL;DR: The effects of noise and imaging parameters on the sensitivity of μOCT-PTM are characterized, which show that the system can accurately quantify viscosities over the range that is characteristic of CF mucus.