G
Greg Lemke
Researcher at Salk Institute for Biological Studies
Publications - 171
Citations - 23946
Greg Lemke is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor tyrosine kinase & Schwann cell. The author has an hindex of 77, co-authored 163 publications receiving 21831 citations. Previous affiliations of Greg Lemke include Howard Hughes Medical Institute & Regeneron.
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Journal ArticleDOI
Neuregulin 1 and Susceptibility to Schizophrenia
Hreinn Stefansson,Engilbert Sigurdsson,Valgerdur Steinthorsdottir,Soley Bjornsdottir,Thordur Sigmundsson,Shyamali Ghosh,J Brynjolfsson,Steinunn Gunnarsdottir,Omar Ivarsson,Thomas T. Chou,Omar Hjaltason,Birgitta Birgisdottir,Helgi Jonsson,Vala G. Gudnadottir,Elsa Gudmundsdottir,Asgeir Björnsson,Brynjolfur Ingvarsson,Andres Ingason,Sigmundur Sigfusson,Hronn Hardardottir,Richard P. Harvey,Richard P. Harvey,Donna Lai,Mingdong Zhou,Daniela Brunner,Vincent Mutel,Acuna Gonzalo,Greg Lemke,Jesus Sainz,Gardar Johannesson,Thorkell Andresson,Daniel F. Gudbjartsson,Andrei Manolescu,Michael L. Frigge,Mark E. Gurney,Augustine Kong,Jeffrey R. Gulcher,Hannes Petursson,Kari Stefansson +38 more
TL;DR: The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
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Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.
Martin Gassmann,Franca Casagranda,Donata Orioli,Horst H. Simon,Cary Lai,Rüdiger Klein,Greg Lemke +6 more
TL;DR: It is demonstrated that ErbB4 is an essential in vivo regulator of both cardiac muscle differentiation and axon guidance in the central nervous system (CNS) and differences in the hindbrain phenotypes of these mutants are consistent with the action of a new Erb B4 ligand in the CNS.
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TAM receptors are pleiotropic inhibitors of the innate immune response.
TL;DR: A self-regulating cycle of inflammation is illuminated, in which the obligatory, cytokine-dependent activation of TAM signaling hijacks a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokines-driven immune responses.
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Immunobiology of the TAM receptors
Greg Lemke,Carla V. Rothlin +1 more
TL;DR: Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
TL;DR: The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.