A
Andreas Zimmer
Researcher at University of Bonn
Publications - 16
Citations - 1502
Andreas Zimmer is an academic researcher from University of Bonn. The author has contributed to research in topics: Receptor & Substance P. The author has an hindex of 13, co-authored 16 publications receiving 1364 citations.
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Journal ArticleDOI
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
Soyoung Lim,Andreas Janzer,Astrid Becker,Andreas Zimmer,Roland Schüle,Reinhard Buettner,Jutta Kirfel +6 more
TL;DR: The data indicate that LSD1 may provide a predictive marker for aggressive biology and a novel attractive therapeutic target for treatment of ER-negative breast cancers.
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Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
Marcella Rietschel,Manuel Mattheisen,Josef Frank,Jens Treutlein,Franziska Degenhardt,René Breuer,Michael Steffens,Daniela Mier,Christine Esslinger,Henrik Walter,Peter Kirsch,Susanne Erk,Knut Schnell,Stefan Herms,H.-Erich Wichmann,Stefan Schreiber,Karl-Heinz Jöckel,Jana Strohmaier,D. Roeske,Britta Haenisch,Magdalena Gross,Susanne Hoefels,Susanne Lucae,Elisabeth B. Binder,Thomas F. Wienker,Thomas G. Schulze,Christine Schmäl,Andreas Zimmer,Dilafruz Juraeva,Benedikt Brors,Thomas Bettecken,Andreas Meyer-Lindenberg,Bertram Müller-Myhsok,Wolfgang Maier,Markus M. Nöthen,Sven Cichon +35 more
TL;DR: The findings of this genome-wide association study suggest that HOMER1 plays a role in the etiology of major depression and that the genetic variation affects depression via the dysregulation of cognitive and motivational processes.
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A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents.
Nina L. Cluny,V.K. Vemuri,Adam P. Chambers,Cheryl L. Limebeer,H Bedard,JodiAnne T. Wood,Beat Lutz,Andreas Zimmer,Linda A. Parker,Alexandros Makriyannis,Keith A. Sharkey +10 more
TL;DR: A novel cannabinoid antagonist designed to have limited CNS penetration is evaluated, to see if it would inhibit food intake in rodents, without aversive effects.
Journal ArticleDOI
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.
Judith Agudo,Miquel Martin,Carles Roca,Maria Molas,A. S. Bura,Andreas Zimmer,Fatima Bosch,Rafael Maldonado +7 more
TL;DR: These results indicate that the lack of CB2R-mediated responses protected mice from both age-related and diet-induced insulin resistance, suggesting that these receptors may be a potential therapeutic target in obesity and insulin resistance.
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Targeting the Cannabinoid Pathway Limits the Development of Fibrosis and Autoimmunity in a Mouse Model of Systemic Sclerosis
Amélie Servettaz,Niloufar Kavian,Carole Nicco,Vanessa Deveaux,Christiane Chéreau,Andrew Wang,Andreas Zimmer,Sophie Lotersztajn,Bernard Weill,Frédéric Batteux +9 more
TL;DR: It is demonstrated that the CB2 receptor is a potential target for the treatment of SSc because it controls both skin fibroblast proliferation and the autoimmune reaction.