K
K Southward
Researcher at University of Leeds
Publications - 6
Citations - 897
K Southward is an academic researcher from University of Leeds. The author has contributed to research in topics: KRAS & Colorectal cancer. The author has an hindex of 6, co-authored 6 publications receiving 761 citations.
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Journal ArticleDOI
Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
Gordon G A Hutchins,K Southward,Kelly Handley,Laura Magill,C Beaumont,Jens Stahlschmidt,Susan D. Richman,Philip A. Chambers,Matthew T. Seymour,David J. Kerr,Richard Gray,Philip Quirke +11 more
TL;DR: The usefulness of defective mismatch repair, BRAF, and KRAS mutations in predicting tumor recurrence and sensitivity to chemotherapy is investigated and MMR assays identify patients with a low risk of recurrence.
Journal ArticleDOI
HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials.
Susan D. Richman,K Southward,Philip A. Chambers,D Cross,Jennifer H. Barrett,Gemma Hemmings,M Taylor,Henry M. Wood,Gordon G A Hutchins,Joseph M. Foster,Assa Oumie,Karen G. Spink,Sarah Brown,Marc Jones,David J. Kerr,Kelly Handley,Richard Gray,Matthew T. Seymour,Philip Quirke +18 more
TL;DR: HER2‐amplification/overexpression is identifiable by immunohistochemistry, occurring infrequently in stage II–III CRC, rising in stage IV and further in KRAS/BRAF WT tumours, and the value of HER2‐targeted therapy in patients with HER2-amplified CRC must be tested in a clinical trial.
Journal ArticleDOI
Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling
Joseph M. Foster,Assa Oumie,Fiona S. Togneri,Fabiana Ramos Vasques,Debra Hau,M Taylor,E Tinkler-Hundal,K Southward,Paul Wallace Medlow,Keith McGreeghan-Crosby,Iris Halfpenny,Dominic J. McMullan,Phil Quirke,Katherine E. Keating,Michael J. Griffiths,Karen G. Spink,Fiona Brew +16 more
TL;DR: Reproducibility of whole-genome copy number, loss of heterozygosity and somatic mutation data using the OncoScan® assay has been demonstrated with comparatively low DNA inputs from a range of highly degraded formalin fixed paraffin embedded samples.
Journal ArticleDOI
Intratumoral stromal morphometry predicts disease recurrence but not response to 5-fluorouracil-results from the QUASAR trial of colorectal cancer.
Hutchins Gga.,Darren Treanor,A Wright,Kelly Handley,Laura Magill,E Tinkler-Hundal,K Southward,Matthew T. Seymour,David J. Kerr,Richard Gray,Philip Quirke +10 more
TL;DR: P prognostic/predictive analyses, and molecular associations, of stromal morphometric quantification in the Quick and Simple and Reliable (QUASAR) trial of CRC are reported.
Journal ArticleDOI
Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations
Simon Gollins,Nicholas P. West,David Sebag-Montefiore,Arthur Sun Myint,Mark P Saunders,Shabbir Susnerwala,Phil Quirke,Sharadah Essapen,Leslie Samuel,Bruce Sizer,Jane Worlding,K Southward,Gemma Hemmings,E Tinkler-Hundal,M Taylor,Daniel Bottomley,Philip A. Chambers,Emma Lawrie,Andre Lopes,Sandy Beare +19 more
TL;DR: For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss.