K
K. Swaminathan Iyer
Researcher at University of Western Australia
Publications - 139
Citations - 3378
K. Swaminathan Iyer is an academic researcher from University of Western Australia. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 29, co-authored 113 publications receiving 2656 citations. Previous affiliations of K. Swaminathan Iyer include Harry Perkins Institute of Medical Research & Flinders University.
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Journal ArticleDOI
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles
Sven Hennig,Sven Hennig,Geraldine Kong,Taro Mannen,Agata Sadowska,Simon Kobelke,Amanda J. Blythe,Gavin J. Knott,K. Swaminathan Iyer,Diwei Ho,Estella A. Newcombe,Kana Hosoki,Naoki Goshima,Tetsuya Kawaguchi,Danny M. Hatters,Laura Trinkle-Mulcahy,Tetsuro Hirose,Charles S. Bond,Archa H. Fox,Archa H. Fox +19 more
TL;DR: Paraspeckles are mammalian subnuclear bodies built on a long noncoding RNA and are enriched in RNA binding proteins with prion-like domains; two of these proteins, RBM14 and FUS, use these domains to hold paraspeckle together.
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The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation
Mihwa Lee,Agata Sadowska,Indra Bekere,Diwei Ho,Benjamin S. Gully,Yanling Lu,K. Swaminathan Iyer,Jill Trewhella,Archa H. Fox,Charles S. Bond +9 more
TL;DR: The coiled-coil interaction motif thus provides a molecular explanation for the functional aggregation of SFPQ that directs its role in regulating many aspects of cellular nucleic acid metabolism.
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Nitrate removal from liquid effluents using microalgae immobilized on chitosan nanofiber mats
Ela Eroglu,Vipul Agarwal,Michael Bradshaw,Xianjue Chen,Steven M. Smith,Colin L. Raston,K. Swaminathan Iyer +6 more
TL;DR: Virtuous nitrate removal rates were derived by superimposing physicochemical adsorption and biological nutrient consumption phenomena for chitosan and microalgae, respectively.
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Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA
Jessica A. Kretzmann,Jessica A. Kretzmann,Diwei Ho,Cameron W. Evans,Janice .H.C. Plani-Lam,Benjamin Garcia-Bloj,A. Elaaf Mohamed,Megan L. O'Mara,Ethan Ford,Ethan Ford,Dennis E.K. Tan,Dennis E.K. Tan,Ryan Lister,Ryan Lister,Pilar Blancafort,Pilar Blancafort,Marck Norret,K. Swaminathan Iyer +17 more
TL;DR: Tools for editing the genome and epigenome have revolutionised the field of molecular biology and represent a new frontier in targeted therapeutic intervention.
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Multimodal analysis of PEI-mediated Endocytosis of Nanoparticles in Neural Cells
Cameron W. Evans,Melinda Fitzgerald,Tristan D. Clemons,Michael J. House,Benjamin S. Padman,Jeremy Shaw,Martin Saunders,Alan R. Harvey,Bogdan Zdyrko,Igor Luzinov,Gabriel A. Silva,Sarah A. Dunlop,K. Swaminathan Iyer +12 more
TL;DR: Detailed insight is provided into how the intracellular delivery of nanoparticles is mediated by polyethylenimine, which is presently the most commonly used nonviral gene transfer agent, and this fundamental knowledge may also assist in the preparation of next-generationnonviral vectors.