K
Kaloyan M. Tsanov
Researcher at Harvard University
Publications - 20
Citations - 794
Kaloyan M. Tsanov is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 7, co-authored 12 publications receiving 526 citations. Previous affiliations of Kaloyan M. Tsanov include Memorial Sloan Kettering Cancer Center & Boston Children's Hospital.
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Journal ArticleDOI
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism
Ng Shyh-Chang,Hao Zhu,T. Yvanka de Soysa,Gen Shinoda,Marc T. Seligson,Kaloyan M. Tsanov,Liem H. Nguyen,John M. Asara,Lewis C. Cantley,Lewis C. Cantley,George Q. Daley +10 more
TL;DR: Lin28a enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics by binding to and enhanced the translation of mRNAs for several metabolic enzymes, thereby increasing glycolysis and oxidative phosphorylation.
Journal ArticleDOI
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma
John T. Powers,Kaloyan M. Tsanov,Daniel S. Pearson,Frederik Roels,Catherine S. Spina,Richard Y. Ebright,Marc T. Seligson,Yvanka de Soysa,Patrick Cahan,Jessica Theißen,Ho-Chou Tu,Areum Han,Kyle C. Kurek,Grace S. LaPier,Jihan K. Osborne,Samantha J. Ross,Marcella Cesana,James J. Collins,James J. Collins,Frank Berthold,George Q. Daley +20 more
TL;DR: This paper found that genetic loss of let-7 is common in neuroblastoma, inversely associated with myCN amplification, and independently associated with poor outcomes, providing a rationale for chromosomal loss patterns in NC.
Journal ArticleDOI
A gene–environment-induced epigenetic program initiates tumorigenesis
Direna Alonso-Curbelo,Yu-Jui Ho,Cassandra Burdziak,Cassandra Burdziak,Jesper L.V. Maag,John P. Morris,Rohit Chandwani,Rohit Chandwani,Hsuan-An Chen,Kaloyan M. Tsanov,Francisco M. Barriga,Wei Luan,Nilgun Tasdemir,Geulah Livshits,Elham Azizi,Jaeyoung Chun,John E. Wilkinson,Linas Mazutis,Steven D. Leach,Steven D. Leach,Richard Koche,Dana Pe'er,Scott W. Lowe,Scott W. Lowe +23 more
TL;DR: In this article, the authors show that the combination of Kras mutation and tissue damage promotes a unique chromatin state in the pancreatic epithelium that distinguishes neoplastic transformation from normal regeneration and is selected for throughout malignant evolution.
Journal ArticleDOI
LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.
Kaloyan M. Tsanov,Daniel S. Pearson,Daniel S. Pearson,Zhaoting Wu,Zhaoting Wu,Areum Han,Areum Han,Robinson Triboulet,Marc T. Seligson,Marc T. Seligson,John T. Powers,John T. Powers,Jihan K. Osborne,Jihan K. Osborne,Susan Kane,Steven P. Gygi,Richard I. Gregory,George Q. Daley,George Q. Daley +18 more
TL;DR: It is shown that LIN28 is phosphorylated by MAPK/ERK in pluripotent stem cells, which increases its levels via post-translational stabilization, and linked this mechanism to the induction of pluripotency by somatic cell reprogramming and the transition from naive to primed pluripOTency.
Journal ArticleDOI
Ordered and deterministic cancer genome evolution after p53 loss
Timour Baslan,John P. Morris,Zhen Zhao,Jose Reyes,Yu-jui Ho,Kaloyan M. Tsanov,Jonathan Bermeo,Shan Tian,Sean Zhang,Gokce Askan,Aslihan Yavas,Nicolas Lecomte,Amanda Erakky,Anna M. Varghese,Amy Zhang,Jude Kendall,Elena Ghiban,Lubomir Chorbadjiev,Jie Wu,Nevenka Dimitrova,Kalyani Chadalavada,Gouri Nanjangud,Chaitanya Bandlamudi,Yixiao Gong,Mark T.A. Donoghue,Nicholas D. Socci,Alexander Krasnitz,Faiyaz Notta,Steven D. Leach,Christine A. Iacobuzio-Donahue,Scott W. Lowe +30 more
TL;DR: In this article , a mouse model of pancreatic ductal adenocarcinoma that reports sporadic p53 loss of heterozygosity before cancer onset was used to find that malignant properties enabled by p53 inactivation are acquired through a predictable pattern of genome evolution.