N
Nilgun Tasdemir
Researcher at University of Pittsburgh
Publications - 30
Citations - 1824
Nilgun Tasdemir is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Invasive lobular carcinoma & Cancer. The author has an hindex of 17, co-authored 30 publications receiving 1320 citations. Previous affiliations of Nilgun Tasdemir include Memorial Sloan Kettering Cancer Center & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
Nilgun Tasdemir,Ana Banito,Jae Seok Roe,Direna Alonso-Curbelo,Matthew Camiolo,Darjus F. Tschaharganeh,Chun-Hao Huang,Ozlem Aksoy,Jessica E. Bolden,Chi-Chao Chen,Myles Fennell,Vishal Thapar,Agustin Chicas,Christopher R. Vakoc,Scott W. Lowe,Scott W. Lowe +15 more
TL;DR: This study reveals how cells undergoing oncogene-induced senescence acquire a distinctive enhancer landscape that includes formation of super-enhancers adjacent to immune-modulatory genes required for paracrine immune activation.
Journal ArticleDOI
The histone chaperone CAF-1 safeguards somatic cell identity
Sihem Cheloufi,Sihem Cheloufi,Ulrich Elling,Barbara Hopfgartner,Youngsook L. Jung,Youngsook L. Jung,Jernej Murn,Jernej Murn,Maria Ninova,Maria Hubmann,Aimee I. Badeaux,Aimee I. Badeaux,Cheen Euong Ang,Danielle Tenen,Danielle Tenen,Daniel J. Wesche,Daniel J. Wesche,Nadezhda Abazova,Nadezhda Abazova,Max Hogue,Max Hogue,Nilgun Tasdemir,Justin Brumbaugh,Justin Brumbaugh,Philipp Rathert,Julian Jude,Francesco Ferrari,Francesco Ferrari,Andres Blanco,Andres Blanco,Michaela Fellner,Daniel Wenzel,Marietta Zinner,Simon E. Vidal,Oliver Bell,Matthias Stadtfeld,Howard Y. Chang,Howard Y. Chang,Geneviève Almouzni,Scott W. Lowe,Scott W. Lowe,John L. Rinn,John L. Rinn,Marius Wernig,Alexei A. Aravin,Yang Shi,Yang Shi,Peter J. Park,Peter J. Park,Josef M. Penninger,Johannes Zuber,Konrad Hochedlinger,Konrad Hochedlinger +52 more
TL;DR: The findings reveal the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting.
Journal ArticleDOI
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
Haluk Yuzugullu,Haluk Yuzugullu,Khemais Benhaj,Nuri Ozturk,Serif Senturk,Emine Celik,Asli Toylu,Nilgun Tasdemir,Mustafa Yilmaz,Esra Erdal,Esra Erdal,Kamil Can Akcali,Neşe Atabey,Mehmet Ozturk,Mehmet Ozturk +14 more
TL;DR: Differential expression of Wnt ligands in HCC cells is associated with selective activation of canonical Wnt signaling in well-differentiated, and its repression in poorly differentiated cell lines, which support the hypothesis that Wnt pathway is selectively activated or repressed depending on differentiation status of H CC cells.
Journal ArticleDOI
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Jun-ichi Sakamaki,Simon Wilkinson,Marcel Hahn,Nilgun Tasdemir,Jim O'Prey,William Clark,Ann Hedley,Colin Nixon,Jaclyn S. Long,Maria New,Tim Van Acker,Sharon A. Tooze,Scott W. Lowe,Scott W. Lowe,Ivan Dikic,Ivan Dikic,Kevin M. Ryan +16 more
TL;DR: It is reported that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB/TFE3/MITF-independent transcriptional program that promotes autophagy and lysosome biogenesis, and is directed independently and also reciprocally to the growth-promoting properties ofBRD4.
Journal ArticleDOI
Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
Jessica E. Bolden,Nilgun Tasdemir,Nilgun Tasdemir,Nilgun Tasdemir,Lukas E. Dow,Johan H. van Es,John E. Wilkinson,Zhen Zhao,Hans Clevers,Scott W. Lowe,Scott W. Lowe +10 more
TL;DR: It is shown that strong suppression of the BET protein Brd4 in adult animals has dramatic effects in multiple tissues, and several potential outcomes associated with potent and sustained BET protein inhibition are predicted.