K
Kalthoum Ben M'barek
Researcher at École Normale Supérieure
Publications - 9
Citations - 403
Kalthoum Ben M'barek is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Lipid droplet & Endoplasmic reticulum. The author has an hindex of 5, co-authored 8 publications receiving 266 citations. Previous affiliations of Kalthoum Ben M'barek include Centre national de la recherche scientifique & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
ER Membrane Phospholipids and Surface Tension Control Cellular Lipid Droplet Formation.
Kalthoum Ben M'barek,Dalila Ajjaji,Aymeric Chorlay,Stefano Vanni,Lionel Foret,Abdou Rachid Thiam +5 more
TL;DR: This work finds that the bilayer phospholipid composition and surface tension are key parameters of LD budding, and reveals the importance of altering ER physical chemistry for controlled cellular LD formation.
Journal ArticleDOI
Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER
Aymeric Chorlay,Luca Monticelli,Joana Veríssimo Ferreira,Kalthoum Ben M'barek,Dalila Ajjaji,Sihui Wang,Errin Johnson,Rainer D. Beck,Mohyeddine Omrane,Mathias Beller,Pedro Carvalho,Abdou Rachid Thiam +11 more
TL;DR: The results reveal an active cooperation between phospholipids and proteins to extract LDs from ER by finding that this directionality is controlled by an asymmetry in monolayer surface coverage.
Journal ArticleDOI
Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.
Dalila Ajjaji,Kalthoum Ben M'barek,Michael L. Mimmack,Cheryl England,Haya Herscovitz,Liang Dong,Richard G. Kay,Satish Patel,Vladimir Saudek,Donald Small,David B. Savage,Abdou Rachid Thiam +11 more
TL;DR: It is suggested that dual amphipathic helical regions mediate LD targeting and underpin the hierarchical binding of Plin1–3 to LDs.
Journal ArticleDOI
Phagocytosis of immunoglobulin-coated emulsion droplets.
Kalthoum Ben M'barek,Kalthoum Ben M'barek,Kalthoum Ben M'barek,Diana Molino,Diana Molino,Diana Molino,Sandrine Quignard,Sandrine Quignard,Sandrine Quignard,Marie-Aude Plamont,Marie-Aude Plamont,Marie-Aude Plamont,Yong Chen,Yong Chen,Yong Chen,Philippe Chavrier,Philippe Chavrier,Jacques Fattaccioli,Jacques Fattaccioli,Jacques Fattaccioli +19 more
TL;DR: Monodisperse, IgG-coated emulsion droplets that are efficiently and specifically internalized by macrophages through in-vitro FcγR-mediated phagocytosis are designed and it is suggested that lateral mobility of proteins at the interface of a target greatly enhances thephagocytic uptake.
Posted ContentDOI
Orp5 and orp8 orchestrate lipid droplet biogenesis and maintenance at er-mitochondria contact sites
Valentin Guyard,Valentin Guyard,Vera F. Monteiro-Cardoso,Vera F. Monteiro-Cardoso,Mohyeddine Omrane,Cécile Sauvanet,Cécile Sauvanet,Audrey Houcine,Claire Boulogne,Kalthoum Ben M'barek,Nicolas Vitale,Orestis Facklaris,Naima El Khallouki,Naima El Khallouki,Abdou Rachid Thiam,Francesca Giordano,Francesca Giordano +16 more
TL;DR: In this article, the lipid transfer proteins ORP5 and ORP8 control LD biogenesis at Mitochondria-associated ER Membrane (MAM) subdomains, enriched in phosphatidic acid.