B
Barbara B. Cochrane
Researcher at University of Washington
Publications - 128
Citations - 11917
Barbara B. Cochrane is an academic researcher from University of Washington. The author has contributed to research in topics: Women's Health Initiative & Risk factor. The author has an hindex of 44, co-authored 122 publications receiving 10882 citations. Previous affiliations of Barbara B. Cochrane include Fred Hutchinson Cancer Research Center & University of Hawaii at Manoa.
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Journal ArticleDOI
Design of the Women's Health Initiative clinical trial and observational study
Garnet L. Anderson,S. Cummings,L. S. Freedman,C. Furberg,Maureen M. Henderson,Susan R. Johnson,L. Kuller,JoAnn E. Manson,A. Oberman,Ross L. Prentice,Jacques E. Rossouw,L. Finnegan,R. Hiatt,L. Pottern,J. McGowan,C. Clifford,B. Caan,V. Kipnis,B. Ettinger,S. Sidney,G. Bailey,Andrea Z. LaCroix,Anne McTiernan,Deborah J. Bowen,C. Chen,Barbara B. Cochrane,Julie R. Hunt,Alan R. Kristal,Brian J. Lund,Ruth E. Patterson,Jeffrey L. Probstfield,Lesley F. Tinker,Nicole Urban,Ching Yun Wang,Emily White,J. M. Kotchen,S. Shumaker,P. Rautaharju,F. Rautaharju,E. Stein,P. Laskarzewski,P. Steiner,K. Sagar,M. Nevitt,M. Dockrell,T. Fuerst,John H. Himes,M. Stevens,F. Cammarata,S. Lindenfelser,Bruce M. Psaty,D. Siscovick,W. Longstreth,S. Heckbert,S. Wassertheil-Smoller,W. Frishman,Judy Wylie-Rosett,D. Barad,R. Freeman,S. Miller,Jennifer Hays,R. Young,C. Crowley,M. A. DePoe,G. Burke,E. Paskett,L. Wagenknecht,R. Crouse,L. Parsons,T. Kotchen,E. Braunwald,J. Buring,C. Hennekens,J. M. Gaziano,Annlouise R. Assaf,R. C. Carleton,M. Miller,C. Wheeler,A. Hume,M. Pedersen,O. Strickland,M. Huber,V. Porter,Shirley A.A. Beresford,V. Taylor,N. Woods,J. Hsia,V. Barnabei,M. Bovun,Rowan T. Chlebowski,R. Detrano,A. Nelson,J. Heiner,S. Pushkin,B. Valanis,V. Stevens,E. Whitlock,N. Karanja,A. Clark +98 more
TL;DR: The rationale for the interventions being studied in each of the CT components and for the inclusion of the OS component is described, including a brief description of the scientific and logistic complexity of the WHI.
Journal ArticleDOI
Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer
Jean Wactawski-Wende,Jane Morley Kotchen,Garnet L. Anderson,Annlouise R. Assaf,Annlouise R. Assaf,Robert L. Brunner,Mary Jo O'Sullivan,Karen L. Margolis,Judith K. Ockene,Lawrence S. Phillips,Linda M. Pottern,Ross L. Prentice,John A Robbins,Thomas E. Rohan,Gloria E. Sarto,Santosh Sharma,Marcia L. Stefanick,Linda Van Horn,Robert B. Wallace,Evelyn P Whitlock,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Denise E. Bonds,Robert G. Brzyski,Bette J. Caan,Rowan T. Chlebowski,Barbara B. Cochrane,Cedric F. Garland,Margery Gass,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Rebecca D. Jackson,Karen C. Johnson,Howard L. Judd,Charles Kooperberg,Lewis H. Kuller,Andrea Z. LaCroix,Dorothy S. Lane,Robert Langer,Norman L. Lasser,Cora E. Lewis,Marian C. Limacher,JoAnn E. Manson +47 more
TL;DR: Daily supplementation of calcium with vitamin D for seven years had no effect on the incidence of colorectal cancer among postmenopausal women, and the long latency associated with the development of colorescopy cancer, along with the seven-year duration of the trial, may have contributed to this null finding.
Journal ArticleDOI
Frailty: Emergence and Consequences in Women Aged 65 and Older in the Women's Health Initiative Observational Study
Nancy Woods,Andrea Z. LaCroix,Shelly L. Gray,Aaron K. Aragaki,Barbara B. Cochrane,Robert L. Brunner,Kamal Masaki,Anne M. Murray,Anne B. Newman +8 more
TL;DR: This work defines frailty using simple indicators and investigates the predictive validity of this frailty classification for death, hospitalization, hip fracture, and activity of daily living disability.
Journal ArticleDOI
Estrogen therapy and coronary-artery calcification.
JoAnn E. Manson,Matthew A. Allison,Jacques E. Rossouw,J. Jeffrey Carr,Robert Langer,Judith Hsia,Lewis H. Kuller,Barbara B. Cochrane,Julie R. Hunt,Shari E. Ludlam,Mary Pettinger,Margery Gass,Karen L. Margolis,Lauren Nathan,Judith K. Ockene,Ross L. Prentice,John A Robbins,Marcia L. Stefanick +17 more
TL;DR: The calcified-plaque burden in the coronary arteries after trial completion was lower in women assigned to estrogen than in those assigned to placebo, however, estrogen has complex biologic effects and may influence the risk of cardiovascular events and other outcomes through multiple pathways.
Journal ArticleDOI
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Jared R. Mayers,Chen Wu,Chen Wu,Clary B. Clish,Peter Kraft,Margaret E. Torrence,Brian P. Fiske,Chen Yuan,Ying Bao,Mary K. Townsend,Shelley S. Tworoger,Shawn M. Davidson,Thales Papagiannakopoulos,Annan Yang,Talya L. Dayton,Shuji Ogino,Shuji Ogino,Meir J. Stampfer,Edward Giovannucci,Zhi Rong Qian,Douglas A. Rubinson,Jing Ma,Howard D. Sesso,John Michael Gaziano,John Michael Gaziano,Barbara B. Cochrane,Simin Liu,Jean Wactawski-Wende,JoAnn E. Manson,Michael Pollak,Alec C. Kimmelman,Amanda Souza,Kerry A. Pierce,Thomas J. Wang,Robert E. Gerszten,Charles S. Fuchs,Charles S. Fuchs,Matthew G. Vander Heiden,Brian M. Wolpin,Brian M. Wolpin +39 more
TL;DR: It is suggested that increased whole-body protein breakdown is an early event in development of PDAC, and elevated plasma levels of branched-chain amino acids (BCAAs) are associated with a greater than twofold increased risk of future pancreatic cancer diagnosis.