K
Karen A. Baskerville
Researcher at Mayo Clinic
Publications - 7
Citations - 404
Karen A. Baskerville is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Cholinergic neuron & Cholinergic. The author has an hindex of 5, co-authored 7 publications receiving 392 citations.
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Journal ArticleDOI
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents
Michelle M. Nicolle,John Gonzalez,Kiminobu Sugaya,Karen A. Baskerville,David Bryan,K Lund,Michela Gallagher,Michael McKinney +7 more
TL;DR: It is concluded that aged hippocampal neurons appear to be under oxidative stress and this is more severe in the learning-impaired subjects, suggesting a possible basis for age-induced cognitive decline.
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Pathway analysis of primary central nervous system lymphoma
Han W. Tun,David Personett,Karen A. Baskerville,David M. Menke,Kurt A. Jaeckle,Pamela A. Kreinest,Brandy Edenfield,Abba C. Zubair,Brian P. O'Neill,Weil R. Lai,Peter J. Park,Michael McKinney +11 more
TL;DR: The gene expression signature discovered in this study may represent a true "CNS signature" because it contrasted PCNSL with wide-spectrum non-CNS DLBCL on a genomic scale and performed an in-depth bioinformatic analysis.
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Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons.
TL;DR: There was a significant loss of cholinergic neurons in aged-impaired animals compared with young subjects, and this selective loss may account for the cognitive deficits observed in aging and, considering previous findings in this model, may be related to oxidative stress.
Journal ArticleDOI
Aging elevates metabolic gene expression in brain cholinergic neurons
Karen A. Baskerville,Caroline Kent,David Personett,Weil R. Lai,Peter J. Park,Paul D. Coleman,Michael McKinney +6 more
TL;DR: The results suggest that aging elicits elevates metabolic activity in cholinergic populations and that this occurs to a much greater degree in the BF group than in the BS group.
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Pontine cholinergic neurons depend on three neuroprotection systems to resist nitrosative stress
Michael McKinney,Katrina Williams,David Personett,Caroline Kent,David Bryan,John Gonzalez,Karen A. Baskerville +6 more
TL;DR: Data indicate that the relative resistance of BS cholinergic neurons to toxic levels of nitric oxide involves three intrinsic neuroprotective pathways that control transcriptional and anti-apoptotic cellular functions.