K
Karen Havenstrite
Researcher at Stanford University
Publications - 11
Citations - 1895
Karen Havenstrite is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 11 publications receiving 1736 citations. Previous affiliations of Karen Havenstrite include Sandia National Laboratories.
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Journal ArticleDOI
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Perturbation of single hematopoietic stem cell fates in artificial niches
Matthias P. Lutolf,Regis Doyonnas,Regis Doyonnas,Karen Havenstrite,Kassie Koleckar,Helen M. Blau +5 more
TL;DR: The results validate the hydrogel microwell platform as a broadly applicable paradigm for dissecting the regulatory role of specific signals within a complex stem cell niche and provide evidence of self-renewal divisions of HSCs in vitro.
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Antibody microarrays for native toxin detection
TL;DR: The development of antibody-based microarray techniques for the multiplexed detection of cholera toxin beta-subunit, diphtheria toxin, anthrax lethal factor and protective antigen, and tetanus toxin C fragment in spiked samples are developed.
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Functional antibody immobilization on 3-dimensional polymeric surfaces generated by reactive ion etching
Victor C. Rucker,Karen Havenstrite,Blake A. Simmons,Shane M. Sickafoose,and Amy E. Herr,Renee Shediac +5 more
TL;DR: This work demonstrates a potentially useful fabrication methodology for constructing antibody microarrays on plastic substrates by patterning antibodies onto the surfaces of polymer substrates using reactive ion etching.
Journal ArticleDOI
Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self-Assembly, Intercellular Transport, and Dual-Mode Cargo Delivery
Victor Y. Lee,Karen Havenstrite,Melia Tjio,Melanie McNeil,Helen M. Blau,Robert D. Miller,Joseph Sly +6 more
TL;DR: This work has shown that star polymers (unimolecular, globular, polymer architectures) are an increasingly attractive class of organic nanoparticles for biomedical research purposes and offer a potential for variation in nanoparticle structure and surface functional.