K
Karen R. Prowse
Researcher at Geron Corporation
Publications - 9
Citations - 8075
Karen R. Prowse is an academic researcher from Geron Corporation. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 5, co-authored 9 publications receiving 7820 citations.
Papers
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
Journal ArticleDOI
Telomerase, Cell Immortality, and Cancer
Calvin B. Harley,Nam Woo Kim,Karen R. Prowse,Scott L. Weinrich,K. S. Hirsch,Michael D. West,Silvia Bacchetti,Hal W. Hirte,Christopher M. Counter,Carol W. Greider,Mieczyslaw Piatyszek,Woodring E. Wright,Jerry W. Shay +12 more
Journal ArticleDOI
Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential
TL;DR: This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential.
Journal ArticleDOI
Telomere length regulation during postnatal development and ageing in Mus spretus
TL;DR: Comparison of the rank order of tissue telomere lengths within individual M. spretus showed that certain tissues tended to be longer than the others, and this ranking also extended to tissues of the M.spretus xC57BL/6 F1 mice, suggesting that telomeres lengths withinindividual tissues are regulated independently and are genetically controlled.
Patent
Methods for measuring telomere length
TL;DR: The methods for measuring telomere length include primer extension-based and probe-based methods as discussed by the authors, which involve elongation of telomeric, linker, and/or subtelomeric based primers under conditions such that the telomeres serves as a template for primer extension and that the resultant primer extension products can be compared to standards of known length to provide a measure of telomeere length.