K
Karen S. King
Researcher at Research Triangle Park
Publications - 23
Citations - 3507
Karen S. King is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Pazopanib & Genome-wide association study. The author has an hindex of 13, co-authored 23 publications receiving 3274 citations. Previous affiliations of Karen S. King include PAREXEL & GlaxoSmithKline.
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Journal ArticleDOI
Genes mirror geography within Europe.
John Novembre,Toby Johnson,Toby Johnson,Katarzyna Bryc,Zoltán Kutalik,Adam R. Boyko,Adam Auton,Amit Indap,Karen S. King,Sven Bergmann,Matthew R. Nelson,Matthew Stephens,Carlos Bustamante +12 more
TL;DR: Despite low average levels of genetic differentiation among Europeans, there is a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans.
Journal ArticleDOI
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
Hao Li,Sally Wetten,Li Li,Pamela L. St. Jean,Ruchi Upmanyu,Linda Surh,David A. Hosford,Michael R. Barnes,James David Briley,Michael Borrie,Natalie Coletta,Richard Delisle,Daniella Dhalla,Margaret G. Ehm,Howard Feldman,Luis Fornazzari,Serge Gauthier,Neil Goodgame,Danilo Guzman,Sandra Hammond,Paul Hollingworth,Ging-Yuek Robin Hsiung,Joan Johnson,Devon D. Kelly,Ron Keren,Andrew Kertesz,Karen S. King,Simon Lovestone,Inge Loy-English,Paul M. Matthews,Michael John Owen,Mary Plumpton,William Pryse-Phillips,Rab K. Prinjha,Jill C. Richardson,Ann M. Saunders,Andrew J. Slater,Peter St George-Hyslop,Sandra W. Stinnett,Jina E. Swartz,Rachel L. Taylor,John Wherrett,Julie Williams,David P. Yarnall,Rachel A. Gibson,Michael C. Irizarry,Lefkos T. Middleton,Allen D. Roses +47 more
TL;DR: The genomewide association analysis again identified the APOE linkage disequilibrium region as the strongest genetic risk factor for AD.
Journal ArticleDOI
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.
Matthew R. Nelson,Katarzyna Bryc,Karen S. King,Amit Indap,Adam R. Boyko,John Novembre,John Novembre,Linda P. Briley,Yuka Maruyama,Dawn M. Waterworth,Gérard Waeber,Peter Vollenweider,Jorge R. Oksenberg,Stephen L. Hauser,Heide A. Stirnadel,Jaspal S. Kooner,John C. Chambers,Brendan Jones,Vincent Mooser,Carlos Bustamante,Allen D. Roses,Daniel K. Burns,Margaret G. Ehm,Eric H. Lai +23 more
TL;DR: In this paper, the authors used the NCBI database of Genotypes and Phenotypes (dbGaP) to genotype and demographic data from 6,000 subjects of African-American, East Asian, South Asian, Mexican, and European origin.
A Resource for Population, Disease, and Pharmacological Genetics Research
Matthew R. Nelson,Katarzyna Bryc,Karen S. King,Amit Indap,Adam R. Boyko,John Novembre,Linda P. Briley,Yuka Maruyama,Dawn M. Waterworth,Peter Vollenweider,Jorge R. Oksenberg,Stephen L. Hauser,Heide A. Stirnadel,Jaspal S. Kooner,John C. Chambers,Brendan Jones,Vincent Mooser,Carlos Bustamante,Allen D. Roses,Daniel K. Burns,Margaret G. Ehm,Eric H. Lai +21 more
TL;DR: It is found that matching based on country of origin, identity-by-state distance, and multidimensional PCA do similarly well to control the type I error rate in a genome-wide analysis of abacavir-associated hypersensitivity reaction.
Journal ArticleDOI
HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer
Colin F. Spraggs,Laura R. Budde,Linda P. Briley,Nan Bing,Charles J. Cox,Karen S. King,John C. Whittaker,Vincent Mooser,A. Preston,S. Stein,Lon R. Cardon +10 more
TL;DR: The results support a role for immune mechanisms in lapatinib-induced hepatotoxicity and further work is required to determine whether testing for DQA1*02:01 allele carriage is clinically useful in managing liver safety risk during Lapatinib treatment.