M
Margaret G. Ehm
Researcher at GlaxoSmithKline
Publications - 52
Citations - 6271
Margaret G. Ehm is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Population & Linkage disequilibrium. The author has an hindex of 28, co-authored 49 publications receiving 5986 citations. Previous affiliations of Margaret G. Ehm include Research Triangle Park.
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Journal ArticleDOI
An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People
Matthew R. Nelson,Daniel Wegmann,Margaret G. Ehm,Darren Kessner,Pamela L. St. Jean,Claudio J. Verzilli,Judong Shen,Zheng-Zheng Tang,Silviu Alin Bacanu,Dana Fraser,Liling Warren,Jennifer L. Aponte,Matthew Zawistowski,Xiao Liu,Hao Zhang,Yong Zhang,Jun Li,Yun Li,Li Li,Peter Woollard,Simon Topp,Matthew D. Hall,Keith Nangle,Jun Wang,Gonçalo R. Abecasis,Lon R. Cardon,Sebastian Zöllner,John C. Whittaker,Stephanie L. Chissoe,John Novembre,Vincent Mooser +30 more
TL;DR: It is concluded that because of rapid population growth and weak purifying selection, human populations harbor an abundance of rare variants, many of which are deleterious and have relevance to understanding disease risk.
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Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals.
Dmitri V. Zaykin,Peter H. Westfall,S. Stanley Young,Maha A Karnoub,Michael J. Wagner,Margaret G. Ehm +5 more
TL;DR: Analysis of real data comprised of a dense map of single nucleotide polymorphisms spaced along a 12-cM chromosomal region allows us to confirm the utility of the haplotype approach as well as the validity and usefulness of the proposed statistical technique.
Journal ArticleDOI
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
Hao Li,Sally Wetten,Li Li,Pamela L. St. Jean,Ruchi Upmanyu,Linda Surh,David A. Hosford,Michael R. Barnes,James David Briley,Michael Borrie,Natalie Coletta,Richard Delisle,Daniella Dhalla,Margaret G. Ehm,Howard Feldman,Luis Fornazzari,Serge Gauthier,Neil Goodgame,Danilo Guzman,Sandra Hammond,Paul Hollingworth,Ging-Yuek Robin Hsiung,Joan Johnson,Devon D. Kelly,Ron Keren,Andrew Kertesz,Karen S. King,Simon Lovestone,Inge Loy-English,Paul M. Matthews,Michael John Owen,Mary Plumpton,William Pryse-Phillips,Rab K. Prinjha,Jill C. Richardson,Ann M. Saunders,Andrew J. Slater,Peter St George-Hyslop,Sandra W. Stinnett,Jina E. Swartz,Rachel L. Taylor,John Wherrett,Julie Williams,David P. Yarnall,Rachel A. Gibson,Michael C. Irizarry,Lefkos T. Middleton,Allen D. Roses +47 more
TL;DR: The genomewide association analysis again identified the APOE linkage disequilibrium region as the strongest genetic risk factor for AD.
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An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.
Robert L. Hanson,Margaret G. Ehm,David J. Pettitt,Michal Prochazka,D. Bruce Thompson,David S. Timberlake,Tatiana Foroud,Sayuko Kobes,Leslie J. Baier,Daniel K. Burns,Laura Almasy,John Blangero,W. Timothy Garvey,Peter H. Bennett,William C. Knowler +14 more
TL;DR: A genomic scan was conducted to identify loci linked to diabetes and body-mass index in Pima Indians, a Native American population with a high prevalence of type II diabetes.
Journal ArticleDOI
Detecting Marker-Disease Association by Testing for Hardy-Weinberg Disequilibrium at a Marker Locus
TL;DR: It does not follow that the usual measures of linkage disequilibrium are zero, but care is needed in the drawing of inferences from marker Hardy-Weinberg disequilibria for disease-susceptibility loci with more than two alleles.