Eric H. Lai

TL;DR: The lower sensitivity of HLA-B57 for predicting hypersensitivity to abacavir identified in this study compared with a previous report highlights that predictive values for markers will vary across populations.

TL;DR: It is found that a high density of markers will be necessary in order to have a good chance of including SNPs with detectable levels of allelic association with the disease mutation, and statistical analysis based on haplotypes can provide additional information with respect to tests of significance and fine localization of complex disease genes.

TL;DR: In this paper, the authors used the NCBI database of Genotypes and Phenotypes (dbGaP) to genotype and demographic data from 6,000 subjects of African-American, East Asian, South Asian, Mexican, and European origin.

TL;DR: It is found that matching based on country of origin, identity-by-state distance, and multidimensional PCA do similarly well to control the type I error rate in a genome-wide analysis of abacavir-associated hypersensitivity reaction.

TL;DR: HLA-B*5701 alone lacks sufficient predictive value to identify patients at risk for hypersensitivity to abacavir across diverse patient populations, and is not associated with hypersensitivity in Blacks or Hispanics.