K
Karen Skorupski
Researcher at Dartmouth College
Publications - 40
Citations - 4184
Karen Skorupski is an academic researcher from Dartmouth College. The author has contributed to research in topics: Vibrio cholerae & Virulence. The author has an hindex of 29, co-authored 40 publications receiving 3938 citations.
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Journal ArticleDOI
Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae
TL;DR: This report identifies and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor and shows that in V.cholerae these communication systems converge to control virulence.
Journal ArticleDOI
Positive selection vectors for allelic exchange
Karen Skorupski,Ronald K. Taylor +1 more
TL;DR: It is shown that these vectors can be used to efficiently introduce point mutations and deletions into the chromosome of Vibrio cholerae.
Journal ArticleDOI
Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli
Karen Skorupski,Ronald K. Taylor +1 more
TL;DR: The recent finding that the global regulator cAMP‐CRP also influences the expression of the ToxR regulon under various environmental conditions raises new issues regarding the pathways and mechanisms by which this regulation is achieved and indicates that multiple overlapping systems are involved.
Journal ArticleDOI
Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter
TL;DR: It is shown here that HapR influences the virulence cascade by directly repressing aphA expression in certain toxigenic Vibrio cholerae strains by function at aphA, which is critical for density‐dependent regulation of virulence genes.
Journal Article
Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter: HapR functions at the aphA promoter
TL;DR: In this article, HapR was shown to influence virulence gene expression by directly repressing aphA expression in certain toxigenic Vibrio cholerae strains, such as C6706 and Escherichia coli.