K
Karen W. Makar
Researcher at Bill & Melinda Gates Foundation
Publications - 83
Citations - 5077
Karen W. Makar is an academic researcher from Bill & Melinda Gates Foundation. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 32, co-authored 83 publications receiving 4267 citations. Previous affiliations of Karen W. Makar include University of Washington & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
BRAF Mutation Status and Survival after Colorectal Cancer Diagnosis According to Patient and Tumor Characteristics
Amanda I. Phipps,Daniel D. Buchanan,Karen W. Makar,Andrea N. Burnett-Hartman,Anna E. Coghill,Michael N. Passarelli,John A. Baron,Dennis J. Ahnen,Aung Ko Win,John D. Potter,Polly A. Newcomb +10 more
TL;DR: The results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
Journal ArticleDOI
Genomic Aberrations Occurring in Subsets of Serrated Colorectal Lesions but not Conventional Adenomas
Andrea N. Burnett-Hartman,Polly A. Newcomb,John D. Potter,Michael N. Passarelli,Amanda I. Phipps,Michelle A. Wurscher,William M. Grady,Lee Ching Zhu,Melissa P. Upton,Karen W. Makar +9 more
TL;DR: It is suggested that SSPs and other large, right-sided serrated lesions have a unique molecular profile that is similar to CIMP-high, BRAF-mutated colorectal cancers.
Journal ArticleDOI
Targeting innate immunity for tuberculosis vaccination.
Shabaana A. Khader,Maziar Divangahi,Willem A. Hanekom,Philip C. Hill,Markus Maeurer,Karen W. Makar,Katrin D. Mayer-Barber,Musa M. Mhlanga,Elisa Nemes,Larry S. Schlesinger,Reinout van Crevel,Ramakrishna Vankalayapati,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea +14 more
TL;DR: Future studies are warranted to explore the untapped potential of trained immunity to develop a future generation of TB vaccines that would combine innate and adaptive immune memory induction.
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Scientific rationale for developing potent RBD-based vaccines targeting COVID-19.
Harry Kleanthous,Judith M. Silverman,Karen W. Makar,In-Kyu Yoon,Nicholas Jackson,D. W. Vaughn +5 more
TL;DR: In this paper, the authors reviewed the data supporting the non-inferiority of RBD as a vaccine immunogen compared to full-length S-protein vaccines with respect to humoral and cellular immune responses against both the prototype pandemic SARS-CoV-2 isolate and emerging variants of concern.
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Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
Sonja I. Berndt,John D. Potter,John D. Potter,Aditi Hazra,Meredith Yeager,Gilles Thomas,Karen W. Makar,Robert Welch,Amanda J. Cross,Wen Yi Huang,Robert E. Schoen,Edward Giovannucci,Andrew T. Chan,Stephen J. Chanock,Ulrike Peters,Ulrike Peters,David J. Hunter,Richard B. Hayes +17 more
TL;DR: This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas.