R
Reinout van Crevel
Researcher at Radboud University Nijmegen
Publications - 275
Citations - 15401
Reinout van Crevel is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Tuberculosis & Medicine. The author has an hindex of 52, co-authored 221 publications receiving 11124 citations. Previous affiliations of Reinout van Crevel include Radboud University Nijmegen Medical Centre & Padjadjaran University.
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Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.
Journal ArticleDOI
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Rob J.W. Arts,Simone J.C.F.M. Moorlag,Boris Novakovic,Yang Li,Shuang-Yin Wang,Marije Oosting,Vinod Kumar,Ramnik J. Xavier,Cisca Wijmenga,Leo A. B. Joosten,Chantal B.E.M. Reusken,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Marion Koopmans,Hendrik G. Stunnenberg,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +19 more
TL;DR: BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain, with a key role for IL-1β as a mediator of trained immunity responses.
Journal ArticleDOI
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Rob J.W. Arts,Boris Novakovic,Rob ter Horst,Agostinho Carvalho,Siroon Bekkering,Ekta Lachmandas,Fernando Rodrigues,Ricardo Silvestre,Shih-Chin Cheng,Shih-Chin Cheng,Shuang-Yin Wang,Ehsan Habibi,Luís G. Gonçalves,Inês Mesquita,Cristina Cunha,Arjan van Laarhoven,Frank L. van de Veerdonk,David L. Williams,Jos W. M. van der Meer,Colin Logie,Luke A. J. O'Neill,Charles A. Dinarello,Charles A. Dinarello,Niels P. Riksen,Reinout van Crevel,Clary B. Clish,Richard A. Notebaart,Leo A. B. Joosten,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +31 more
TL;DR: Identification of the metabolic pathways leading to induction of trained immunity contributes to the understanding of innate immune memory and opens new therapeutic avenues.
Journal ArticleDOI
Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Christine Stabell Benn,Leo A. B. Joosten,Cor Jacobs,Joke van Loenhout,Ramnik J. Xavier,Peter Aaby,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +11 more
TL;DR: BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at thelevel of heterologous Th1/Th17 responses 1 year after vaccination.
Journal ArticleDOI
Immunometabolic pathways in BCG-induced trained immunity
Rob J.W. Arts,Agostinho Carvalho,Claudia La Rocca,Carla Palma,Fernando Rodrigues,Ricardo Silvestre,Johanneke Kleinnijenhuis,Ekta Lachmandas,Luís G. Gonçalves,Ana Belinha,Cristina Cunha,Marije Oosting,Leo A. B. Joosten,Giuseppe Matarese,Reinout van Crevel,Mihai G. Netea +15 more
TL;DR: It is shown that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after vaccination of mice and humans.