M
Meredith Yeager
Researcher at Leidos
Publications - 407
Citations - 28381
Meredith Yeager is an academic researcher from Leidos. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 77, co-authored 391 publications receiving 25750 citations. Previous affiliations of Meredith Yeager include Science Applications International Corporation & Advanced Technology Center.
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Journal ArticleDOI
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
David J. Hunter,David J. Hunter,Peter Kraft,Kevin B. Jacobs,David G. Cox,Meredith Yeager,Meredith Yeager,Susan E. Hankinson,Sholom Wacholder,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Amy Hutchinson,Amy Hutchinson,Junwen Wang,Junwen Wang,Kai Yu,Nilanjan Chatterjee,Nick Orr,Walter C. Willett,Graham A. Colditz,Regina G. Ziegler,Christine D. Berg,Saundra S. Buys,Catherine A. McCarty,Heather Spencer Feigelson,Eugenia E. Calle,Michael J. Thun,Richard B. Hayes,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,Gilles Thomas,Stephen J. Chanock +35 more
TL;DR: Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies.
Journal ArticleDOI
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Meredith Yeager,Nick Orr,Richard B. Hayes,Kevin B. Jacobs,Peter Kraft,Sholom Wacholder,Mark J Minichiello,Paul Fearnhead,Kai Yu,Nilanjan Chatterjee,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Brian Staats,Brian Staats,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Geraldine Cancel-Tassin,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,Edward P. Gelmann,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,David J. Hunter,David J. Hunter,Stephen J. Chanock,Gilles Thomas +38 more
TL;DR: Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.
Journal ArticleDOI
Multiple loci identified in a genome-wide association study of prostate cancer
Gilles Thomas,Kevin B. Jacobs,Meredith Yeager,Meredith Yeager,Peter Kraft,Sholom Wacholder,Nick Orr,Kai Yu,Nilanjan Chatterjee,Robert W Welch,Robert W Welch,Amy Hutchinson,Amy Hutchinson,Andrew Crenshaw,Andrew Crenshaw,Geraldine Cancel-Tassin,Brian Staats,Brian Staats,Zhaoming Wang,Zhaoming Wang,Jesus Gonzalez-Bosquet,Jun Fang,Xiang Deng,Xiang Deng,Sonja I. Berndt,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,E. David Crawford,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,Richard B. Hayes,David J. Hunter,David J. Hunter,Stephen J. Chanock +46 more
TL;DR: The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals.
Journal ArticleDOI
Natural selection at major histocompatibility complex loci of vertebrates
Austin L. Hughes,Meredith Yeager +1 more
TL;DR: Four independent lines of evidence support the hypothesis that MHC polymorphisms are selectively maintained, andIntrons have been homogenized relative to exons over evolutionary time, suggesting that balancing selection acts to maintain diversity in the latter, in contrast to the former.
Journal ArticleDOI
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
Montserrat Garcia-Closas,Núria Malats,Debra T. Silverman,Mustafa Dosemeci,Manolis Kogevinas,David W. Hein,Adonina Tardón,Consol Serra,Alfredo Carrato,Reina García-Closas,Josep Lloreta,Gemma Castaño-Vinyals,Meredith Yeager,Robert Welch,Stephen J. Chanock,Nilanjan Chatterjee,Sholom Wacholder,Claudine Samanic,Montserrat Torà,Francisco J. Martín Fernández,Francisco X. Real,Nathaniel Rothman +21 more
TL;DR: The GSTM1 null genotypes increases the overall risk of bladder cancer, and the NAT2 slow-acetylator genotype increases risk particularly among cigarette smokers, providing compelling evidence for the role of common polymorphisms in the aetiology of cancer.