D
D. W. Vaughn
Researcher at Bill & Melinda Gates Foundation
Publications - 14
Citations - 867
D. W. Vaughn is an academic researcher from Bill & Melinda Gates Foundation. The author has contributed to research in topics: Japanese encephalitis & Complementary DNA. The author has an hindex of 10, co-authored 14 publications receiving 684 citations.
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Journal ArticleDOI
HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais
Henry A.F. Stephens,Henry A.F. Stephens,R. Klaythong,Monchan Sirikong,D. W. Vaughn,Sharone Green,Siripen Kalayanarooj,Timothy P. Endy,Daniel H. Libraty,A. Nisalak,Bruce L. Innis,Alan L. Rothman,Francis A. Ennis,Dasnayanee Chandanayingyong +13 more
TL;DR: It is confirmed that classical HLA class I alleles are associated with the clinical outcome of exposure to dengue virus, in previously exposed and immunologically primed individuals.
Journal ArticleDOI
Safety and immunogenicity of attenuated dengue virus vaccines (Aventis Pasteur) in human volunteers
Niranjan Kanesa-thasan,Wellington Sun,G. J. Kim-Ahn,S. Van Albert,Joseph R. Putnak,Alan D. King,B. Raengsakulsrach,H. Christ-Schmidt,K. Gilson,J.M. Zahradnik,D. W. Vaughn,Bruce L. Innis,Jean-François Saluzzo,Charles H. Hoke +13 more
TL;DR: The AvP live attenuated tetravalent d Dengue vaccine was most reactogenic, and preferential replication of dengue-3 virus may have affected its infectivity and immunogenicity.
Journal ArticleDOI
Evaluation of post-introduction COVID-19 vaccine effectiveness: Summary of interim guidance of the World Health Organization.
Minal K. Patel,Isabel Bergeri,Joseph S. Bresee,Benjamin J. Cowling,Natasha S. Crowcroft,Kamal Fahmy,Siddhivinayak Hirve,Gagandeep Kang,Mark A. Katz,Claudio F. Lanata,Maïna L'Azou Jackson,Sudhir Joshi,Marc Lipsitch,Jason M. Mwenda,Francisco Nogareda,Walter A. Orenstein,Justin R. Ortiz,Richard Pebody,Stephanie J. Schrag,Pete Smith,Padmini Srikantiah,Lorenzo Subissi,Marta Valenciano,D. W. Vaughn,Jennifer R. Verani,Annelies Wilder-Smith,Daniel R. Feikin +26 more
TL;DR: The interim best practice guidance for COVID-19 vaccine effectiveness evaluation is presented in this paper, where the authors present a summary of the interim guidance, including discussion of different study designs, priority outcomes to evaluate, potential biases, existing surveillance platforms that can be used, and recommendations for reporting results.
Journal ArticleDOI
Scientific rationale for developing potent RBD-based vaccines targeting COVID-19.
Harry Kleanthous,Judith M. Silverman,Karen W. Makar,In-Kyu Yoon,Nicholas Jackson,D. W. Vaughn +5 more
TL;DR: In this paper, the authors reviewed the data supporting the non-inferiority of RBD as a vaccine immunogen compared to full-length S-protein vaccines with respect to humoral and cellular immune responses against both the prototype pandemic SARS-CoV-2 isolate and emerging variants of concern.
Journal ArticleDOI
Phase 1 studies of walter reed army institute of research candidate attenuated dengue vaccines: selection of safe and immunogenic monovalent vaccines
Niranjan Kanesa-thasan,Robert R. Edelman,C O Tacket,Steven S. Wasserman,D. W. Vaughn,T. S. Coster,G. J. Kim-Ahn,Doria R. Dubois,Joseph R. Putnak,Alan D. King,P. L. Summers,Bruce L. Innis,Kenneth H. Eckels,Charles H. Hoke +13 more
TL;DR: Initial safety testing of 10 live-attenuated dengue virus (DENV) vaccine candidates modified by serial passage in primary dog kidney (PDK) cells at the Walter Reed Army Institute of Research found three vaccine candidates were associated with transient idiosyncratic reactions in one volunteer each, resulting in their withdrawal from further clinical development.