K
Karin A. Mattern
Researcher at Erasmus University Rotterdam
Publications - 4
Citations - 336
Karin A. Mattern is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Telomere-binding protein & Fluorescence recovery after photobleaching. The author has an hindex of 3, co-authored 3 publications receiving 316 citations.
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Journal ArticleDOI
Compartmentalization of androgen receptor protein–protein interactions in living cells
Martin E. van Royen,Sónia M. Cunha,Maartje C. Brink,Karin A. Mattern,Alex L. Nigg,Hendrikus J. Dubbink,Pernette J. Verschure,Jan Trapman,Adriaan B. Houtsmuller +8 more
TL;DR: Evidence is provided that AR N/C interactions occur predominantly when ARs are mobile, possibly to prevent unfavorable or untimely cofactor interactions and to maintain spatiotemporal organization of AR coregulators.
Journal ArticleDOI
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.
Karin A. Mattern,Susan J. J. Swiggers,Alex L. Nigg,Bob Löwenberg,Adriaan B. Houtsmuller,J. Mark J. M. Zijlmans +5 more
TL;DR: The data support a dynamic model of telomeres in which chromosome end-protection and telomere length homeostasis are governed by differential binding of telomeric proteins to telomersic DNA.
Book ChapterDOI
Fluorescence recovery after photobleaching (FRAP) to study nuclear protein dynamics in living cells.
Martin E. van Royen,Pascal Farla,Karin A. Mattern,Bart Geverts,Jan Trapman,Adriaan B. Houtsmuller +5 more
TL;DR: Detailed protocols for some of the FRAP procedures used to study protein behaviour in living cell nuclei are provided and examples of their application in the investigation of the androgen receptor, a hormone-inducible transcription factor, and of two DNA-maintenance factors, the telomere binding proteins TRF1 and TRF2 are provided.
Journal ArticleDOI
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.
Joscha Mulorz,Joshua M. Spin,Pireyatharsheny Mulorz,Markus U. Wagenhäuser,Alicia Deng,Karin A. Mattern,Y. Rhee,Kensuke Toyama,Matti Adam,Hubert Schelzig,Lars Maegdefessel,Philip S. Tsao +11 more
TL;DR: In this article , the impact of daily e-cig vaping with nicotine on abdominal aortic aneurysm (AAA) was evaluated using two complementary murine models and found that exposure enhanced AAA development in both models and genders.