Matti Adam

TL;DR: The current review focuses on the relationship between diabetes-induced CVD and oxidative stress, while highlighting the latest insights into this relationship from findings on diabetic heart and vascular disease.

TL;DR: In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells.

TL;DR: The identification of MPO as a central player in inflammation renders this enzyme an attractive prognostic biomarker and a potential target for therapeutic interventions.

TL;DR: The novel concept of segmental aortic stiffening as an early pathomechanism generating aorti wall stress and triggering aneurysmal growth is introduced, delineating potential underlying molecular mechanisms and therapeutic targets.

TL;DR: This review summarizes the current knowledge of pathomechanisms involved in aortic valve calcification and points out novel treatment strategies.