Karin Bundschu

TL;DR: It is shown that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility, supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca2+ levels.

TL;DR: An overview of this new field is given and the domain functions, binding partners, expression patterns and the cellular localizations, regulations and functions of Spred proteins are summarized to give perspectives for future scientific directions.

TL;DR: In this paper, a direct repression of Isl1 by Nkx2-5 is shown to be necessary for proper development of the ventricular myocardial lineage in mouse embryonic stem cells (ESCs).

TL;DR: These findings provide an Isl1/Nkx2‐5‐mediated mechanism that coordinately regulates the specification of cardiac progenitors toward the different myocardial lineages and ensures proper acquisition of myocyte subtype identity.

TL;DR: It is concluded that the two members of the recently discovered Spred protein family show a highly specific expression pattern in various tissues reflecting a specific physiological role for the individual Spred isoforms in these tissues.